Studies investigating the proteome of skeletal muscle present clear evidence that protein
metabolism is altered in muscle of humans with obesity. Moreover, muscle quality (ie …

Improving the health of skeletal muscle is an important component of obesity treatment.
Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the …

Body composition in obesity is characterized by elevated fat mass but also lean body mass
which is considered either increased or decreased (in the case of sarcopenic obesity). Thus …

Obesity may impair protein synthesis rates and cause anabolic resistance to growth factors,
hormones, and exercise, ultimately affecting skeletal muscle mass and function. To better …

This pilot experiment examines if a loss in muscle proteostasis occurs in people with obesity
and whether endurance exercise positively influences either the abundance profile or …

Objective Obesity alters protein metabolism in skeletal muscle, but consistent evidence is
lacking. This study compared muscle protein synthesis in adults with obesity and in lean …

Key points• Prolonged obesity leads to ectopic lipid accumulation in non‐adipose tissues,
particularly in skeletal muscles, inducing metabolic dysfunctions (reduced glucose uptake …

Context: Obesity-related insulin resistance of glucose and lipid metabolism may also affect
protein kinetics, notably at the muscle level. Objective: We hypothesized that muscle protein …

Metabolic and structural changes in skeletal muscle that accompany obesity are often
associated with the development of insulin resistance. The first events in the pathogenesis of …

Skeletal muscle demonstrates extraordinary mutability in its responses to exercise of
different modes, intensity, and duration, which must involve alterations of muscle protein …