FBW7 functions as a tumor suppressor by targeting oncoproteins for degradation. Our
previous study found FBW7 was low expressed in pancreatic cancer due to sustained …

Purpose: FBW7 functions as a tumor suppressor by targeting oncoproteins for destruction.
We previously reported that the oncogenic mutation of KRAS inhibits the tumor suppressor …

Pancreatic cancer cells undergo intricate metabolic reprogramming to sustain their survival
and proliferation. p53 exhibits a dual role in tumor cell ferroptosis. However, the precise role …

Abstract FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor,
which promotes the ubiquitination and subsequent degradation of numerous oncoproteins …

FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-
suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its …

Pancreatic cancer is a common gastrointestinal tract malignancy. Currently, the therapeutic
strategies for pancreatic cancers include surgery, radiotherapy, and chemotherapy; …

Pancreatic cancer is a highly fatal malignant tumor of the digestive system. It is characterized
by early metastasis and high mortality rates. Solasonine, a steroidal alkaloid, is derived from …

Ferroptosis is a novel form of cell death that is closely associated with the formation of many
tumors. Our study focused on the mechanism by which long noncoding RNAs (lncRNAs) …

Pancreatic ductal adenocarcinoma (PDAC) remains a highly fatal malignancy partially due
to the acquired alterations related to aberrant protein glycosylation that pathologically …

Background The tumor suppressor FBW7 is the substrate recognition component of the SCF
E3-ubiquitin ligase complex that mediates proteolytic degradation of various oncogenic …