[HTML][HTML] FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells
Z Ye, Q Zhuo, Q Hu, X Xu, Z Zhang, W Xu, W Liu, G Fan… - Redox biology, 2021 - Elsevier
FBW7 functions as a tumor suppressor by targeting oncoproteins for degradation. Our
previous study found FBW7 was low expressed in pancreatic cancer due to sustained …
previous study found FBW7 was low expressed in pancreatic cancer due to sustained …
FBW7 (F-box and WD repeat domain-containing 7) negatively regulates glucose metabolism by targeting the c-Myc/TXNIP (thioredoxin-binding protein) axis in …
S Ji, Y Qin, C Liang, R Huang, S Shi, J Liu, K Jin… - Clinical Cancer …, 2016 - AACR
Purpose: FBW7 functions as a tumor suppressor by targeting oncoproteins for destruction.
We previously reported that the oncogenic mutation of KRAS inhibits the tumor suppressor …
We previously reported that the oncogenic mutation of KRAS inhibits the tumor suppressor …
SLC35F2–SYVN1–TRIM59 axis critically regulates ferroptosis of pancreatic cancer cells by inhibiting endogenous p53
B Che, Y Du, R Yuan, H Xiao, W Zhang, J Shao, H Lu… - Oncogene, 2023 - nature.com
Pancreatic cancer cells undergo intricate metabolic reprogramming to sustain their survival
and proliferation. p53 exhibits a dual role in tumor cell ferroptosis. However, the precise role …
and proliferation. p53 exhibits a dual role in tumor cell ferroptosis. However, the precise role …
[HTML][HTML] Aberrant regulation of FBW7 in cancer
L Wang, X Ye, Y Liu, W Wei, Z Wang - Oncotarget, 2014 - ncbi.nlm.nih.gov
Abstract FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor,
which promotes the ubiquitination and subsequent degradation of numerous oncoproteins …
which promotes the ubiquitination and subsequent degradation of numerous oncoproteins …
[HTML][HTML] Tumor suppressor functions of FBW7 in cancer development and progression
Z Wang, H Inuzuka, J Zhong, L Wan, H Fukushima… - FEBS letters, 2012 - Elsevier
FBW7 (F-box and WD repeat domain-containing 7) has been characterized as an onco-
suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its …
suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its …
[HTML][HTML] Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis
X Liu, X Peng, S Cen, C Yang, Z Ma… - Frontiers in Pharmacology, 2023 - frontiersin.org
Pancreatic cancer is a common gastrointestinal tract malignancy. Currently, the therapeutic
strategies for pancreatic cancers include surgery, radiotherapy, and chemotherapy; …
strategies for pancreatic cancers include surgery, radiotherapy, and chemotherapy; …
[HTML][HTML] Solasonine inhibits pancreatic cancer progression with involvement of ferroptosis induction
X Liang, C Hu, M Han, C Liu, X Sun, K Yu, H Gu… - Frontiers in …, 2022 - frontiersin.org
Pancreatic cancer is a highly fatal malignant tumor of the digestive system. It is characterized
by early metastasis and high mortality rates. Solasonine, a steroidal alkaloid, is derived from …
by early metastasis and high mortality rates. Solasonine, a steroidal alkaloid, is derived from …
[HTML][HTML] The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination
G Huang, Z Xiang, H Wu, Q He, R Dou… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Ferroptosis is a novel form of cell death that is closely associated with the formation of many
tumors. Our study focused on the mechanism by which long noncoding RNAs (lncRNAs) …
tumors. Our study focused on the mechanism by which long noncoding RNAs (lncRNAs) …
[HTML][HTML] Targeting N-glycosylation of 4F2hc mediated by glycosyltransferase B3GNT3 sensitizes ferroptosis of pancreatic ductal adenocarcinoma
H Ma, X Chen, S Mo, Y Zhang, X Mao, J Chen… - Cell Death & …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) remains a highly fatal malignancy partially due
to the acquired alterations related to aberrant protein glycosylation that pathologically …
to the acquired alterations related to aberrant protein glycosylation that pathologically …
[HTML][HTML] FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2
F Xu, J Li, M Ni, J Cheng, H Zhao, S Wang, X Zhou… - Molecular cancer, 2021 - Springer
Background The tumor suppressor FBW7 is the substrate recognition component of the SCF
E3-ubiquitin ligase complex that mediates proteolytic degradation of various oncogenic …
E3-ubiquitin ligase complex that mediates proteolytic degradation of various oncogenic …