Pancreatic cancer (PC) is very deadly and difficult to treat. The presence of hypoxia has
been shown to increase the probability of cancer developing and spreading. Pancreatic …

Background Pancreatic cancer is one of the representative solid tumors, in which the
hypoxic microenvironment plays a crucial role in malignant progression. We previously …

The hypoxic environment in tumor is reported to play an important role in pancreatic cancer
progression. The interaction between stromal and cancer cells also contributes to the …

Hepatocyte growth facor activator (HGFA) is a serine protease that converts hepatocyte
growth factor (HGF) into its active form. Our previous study demonstrated that tumor–stromal …

Intratumoral hypoxia is a common feature of solid tumors. Recent advances in cancer
biology indicate that hypoxia is not only a consequence of unrestrained tumor growth, but …

Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …

Hypoxia is known to play critical roles in cell survival, angiogenesis, tumor invasion, and
metastasis. Hypoxia mediated over-expression of hypoxia-inducible factor (HIF) has been …

Hypoxia unleashes the invasive and metastatic potential of tumor cells by largely unknown
mechanisms. The Met tyrosine kinase, a high affinity receptor for hepatocyte growth factor …

Pancreatic tumors are renowned for their extremely hypoxic centers, resulting in
upregulation of a number of hypoxia mediated signaling pathways including cell …

The correlation between hypoxia and pancreatic cancer has long been discussed. Hao's
research team made many efforts on revealing the oncogenic function of hypoxic inducible …