Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Nuclear receptors are classically defined as ligand-activated transcription factors that
regulate key functions in reproduction, development, and physiology. Humans have 48 …

Nuclear receptors (NRs) have historically been at the forefront of cancer research, where
they are known to act as critical regulators of disease. They also serve as biomarkers for …

A central theme that defines the field of endocrinology is the act of controlling activities and
processes at distal sites in the body. Signaling molecules, in some cases nonprotein small …

The nuclear receptor superfamily comprises a large group of proteins with functions
essential for cell signaling, survival, and proliferation. There are multiple distinctions …

Nuclear receptors are major targets for drug discovery and have key roles in development
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …

Because of their central importance in gene regulation and mediating the actions of many
hormones, the nuclear receptors (NRs) have long been recognized as very important …

Nuclear receptors (NR) are ligand-activated transcription factors that regulate the activation
of a variety of important target genes. There are 48 genes that encode NRs in the human …

Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …

Until recently, the study of nuclear receptor (NR) function in breast cancer biology has been
largely limited to estrogen and progesterone receptors. The development of reliable gene …