Whole cell-based phenotypic screens have become the primary mode of hit generation in
tuberculosis (TB) drug discovery during the last two decades. Different drug screening …

Current tuberculosis (TB) drug development efforts are not sufficient to end the global TB
epidemic. Recent efforts have focused on the development of whole-cell screening assays …

Tuberculosis (TB) is an infectious disease, infecting a quarter of world's population. Drug
resistant TB further exacerbates the grim scenario of the drying TB drug discovery pipeline …

More than two decades have elapsed since the publication of the first genome sequence of
Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine …

Conspectus Tuberculosis (TB) is the leading cause of mortality globally resulting from an
infectious disease, killing almost 1.6 million people annually and accounting for …

Highlights•Prodrugs are over-represented among hits from phenotypic
screens.•Hypomorphs are versatile tools for use in TB drug target validation.•Innovative …

New drugs that retain potency against multidrug/extensively drug-resistant strains of
Mycobacterium tuberculosis, with the additional benefit of a shortened treatment duration …

Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis (TB), a disease
that, although preventable and curable, remains a global epidemic due to the emergence of …

The tuberculosis (TB) drug discovery pipeline is fueled by compounds identified in whole-
cell screens against the causative agent, Mycobacterium tuberculosis. Phenotypic screening …

Opinion statement Tuberculosis (TB) is a devastating infectious disease that continues to
plague the world, despite improved hygiene, massive vaccination efforts and an arsenal of …