Brain metastases are a serious obstacle in the treatment of patients with solid tumors and
contribute to the morbidity and mortality of these cancers. It is speculated that the frequency …

An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …

Brain metastasis is a major cause of systemic cancer morbidity and mortality. Many factors
participate in the development and maintenance of brain metastases. The survival of the …

Many patients with lung cancer, breast cancer, and melanoma develop brain metastases
that are resistant to conventional therapy. The median survival for untreated patients is 1 to 2 …

Brain metastasis is a major public health problem. An alarming increase in the incidence of
brain metastasis in patients with otherwise well controlled systemic cancer has drawn …

Metastases are the most common tumors of the central nervous system (CNS), but cancer
databases are often incomplete leading to underestimation of the incidence of even …

Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and
melanoma, is associated with poor survival outcomes and poses distinct clinical challenges …

Brain metastases are the most common intracranial malignancy, accounting for significant
morbidity and mortality in oncology patients. The current treatment paradigm for brain …

The metastasis of cancer to the central nervous system (CNS) remains a devastating clinical
reality, carrying an estimated survival time of less than one year in spite of recent therapeutic …

Metastatic tumours involving the brain overshadow primary brain neoplasms in frequency
and are an important complication in the overall management of many cancers. Importantly …