Introduction: The ongoing surge of resistance of bacterial pathogens to antibiotic therapies
and the consistently aging median member of the human race signal an impending increase …

This article provides a critical view of the current state of the development of nanoparticulate
and other solid-state carriers for the local delivery of antibiotics in the treatment of …

Bone infections are devastating complications in orthopedics due to biofilm formation.
Treatment requires high antibiotic doses, which may lead to systemic toxicity thus limiting the …

Today's human society, product of decades of progress in all fields of knowledge, would
have been unimaginable without the discovery of antibiotics and more generally of …

Development of a material for simultaneous sustained and localized delivery of antibiotics
and induction of spontaneous regeneration of hard tissues affected by osteomyelitis stands …

Intracellular pathogenic bacteria can lead to some of the most life-threatening infections. By
evolving a number of ingenious mechanisms, these bacteria have the ability to invade …

Development of new delivery systems that deliver the potential drug specifically to the target
site in order to meet the therapeutic needs of the patients at the required time and level …

Biofilms are highly tolerant to antimicrobial agents and adverse environmental conditions
being important reservoirs for chronic and hard-to-treat infections. Nanomaterials exhibit …

Ther. Deliv.(2013) 4 (6) 644 future science group so far [8]. Fourth, they could be prepared in
nanoform and in a variety of morphologies using simple and eco-friendly precipitation …

The treatment of bone infections still involves systemic or local antibiotic therapy in high
doses for prolonged periods. Current research focuses on the application of different drug …