Kratom Alkaloid Mitragynine: Therapeutic Role and Basis of Potential Utility Against Chemotherapy-Induced Peripheral Neuropathy
DJ Farkas - 2023 - search.proquest.com
Chronic neuropathic pain is a leading cause of disability worldwide and is associated with
immense economic burden. Of all chronic neuropathic pain conditions, chemotherapy …
immense economic burden. Of all chronic neuropathic pain conditions, chemotherapy …
Kratom Alkaloid Mitragynine: Therapeutic Role and Potential Utility Against Chemotherapy-Induced Peripheral Neuropathy
D Farkas - 2023 - scholarshare.temple.edu
Chronic neuropathic pain is a leading cause of disability worldwide and is associated with
immense economic burden. Of all chronic neuropathic pain conditions, chemotherapy …
immense economic burden. Of all chronic neuropathic pain conditions, chemotherapy …
[HTML][HTML] Kratom alkaloid mitragynine: Inhibition of chemotherapy-induced peripheral neuropathy in mice is dependent on sex and active adrenergic and opioid …
DJ Farkas, JD Foss, SJ Ward, SM Rawls - IBRO Neuroscience Reports, 2022 - Elsevier
Mitragynine (MG) is an alkaloid found in Mitragyna speciosa (kratom) that is used as an
herbal remedy for pain relief and opioid withdrawal. MG acts at μ-opioid and α-adrenergic …
herbal remedy for pain relief and opioid withdrawal. MG acts at μ-opioid and α-adrenergic …
Kratom Alkaloid Mitragynine: Inhibition of Chemotherapy-Induced Peripheral Neuropathy in Mice is Dependent on Sex and Adrenergic and Opioid Receptors
D Farkas, J Foss, S Ward, S Rawls - Authorea Preprints, 2022 - authorea.com
Background and Purpose: Mitragynine (MG) is an alkaloid found in Mitragyna speciosa
(kratom) that is used as an herbal remedy for pain relief and opioid withdrawal. MG acts at μ …
(kratom) that is used as an herbal remedy for pain relief and opioid withdrawal. MG acts at μ …
Efficacy and Receptor Activity of Mitragynine and Speciogynine in Attenuating Cancer-Induced Bone Pain Associated Mechanical Allodynia
YT Ortiz, S Mukhopadhyay, CR McCurdy… - The Journal of …, 2024 - jpain.org
Cancer patients commonly experience neuropathic pain caused by tumor metastasis to
bone, known as cancer-induced bone pain (CIPB). There are currently no curative …
bone, known as cancer-induced bone pain (CIPB). There are currently no curative …
Mitragynine, bioactive alkaloid of kratom, reduces chemotherapy-induced neuropathic pain in rats through α-adrenoceptor mechanism
JD Foss, SU Nayak, CS Tallarida, DJ Farkas… - Drug and Alcohol …, 2020 - Elsevier
Abstract Background and Purpose Kratom is a coffee-like plant containing compounds that
cause opioid and stimulant effects. The most prevalent bioactive alkaloid of kratom is …
cause opioid and stimulant effects. The most prevalent bioactive alkaloid of kratom is …
Cannabidiol and mitragynine exhibit differential interactive effects in the attenuation of paclitaxel-induced mechanical allodynia, acute antinociception, and schedule …
YT Ortiz, JA Bilbrey, JS Felix, EA Kienegger… - Pharmacological …, 2023 - Springer
Background For many chemotherapy patients peripheral neuropathy is a debilitating side
effect. Mitragyna speciosa (kratom) contains the alkaloid mitragynine (MG), which produces …
effect. Mitragyna speciosa (kratom) contains the alkaloid mitragynine (MG), which produces …
Chemical composition and biological effects of kratom (Mitragyna speciosa): In vitro studies with implications for efficacy and drug interactions
The safety and efficacy of kratom (Mitragyna speciosa) for treatment of pain is highly
controversial. Kratom produces more than 40 structurally related alkaloids, but most studies …
controversial. Kratom produces more than 40 structurally related alkaloids, but most studies …
Kratom Alkaloids, Cannabinoids, and Chronic Pain: Basis of Potential Utility and Role in Therapy
DJ Farkas, ZD Cooper, LN Heydari… - Cannabis and …, 2023 - liebertpub.com
Introduction: Chronic neuropathic pain is as a severe detriment to overall quality of life for
millions of Americans. Current pharmacological treatment options for chronic neuropathic …
millions of Americans. Current pharmacological treatment options for chronic neuropathic …
Polypharmacology of Mitragyna speciosa (“kratom”) alkaloids
Y Chen - 2023 - search.proquest.com
The nation's persistent opioid epidemic requires innovative treatment interventions.
Mitragyna speciosa, or kratom, is a plant native to Southeast Asia that contains dozens of …
Mitragyna speciosa, or kratom, is a plant native to Southeast Asia that contains dozens of …