The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways

H Kang, W Zhang, J Jing, D Huang, L Zhang… - Journal of Hazardous …, 2023 - Elsevier
The production of plastic is still increasing globally, which has led to an increasing number
of plastic particles in the environment. Nanoplastics (NPs) can penetrate the blood-brain …

Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson's disease-like neurodegeneration by causing energy …

B Liang, Y Huang, Y Zhong, Z Li, R Ye, B Wang… - Journal of Hazardous …, 2022 - Elsevier
With the prevalence of nanoplastics in daily life, human exposure is inevitable. However,
whether and how nanoplastics cause neurotoxicity in humans remains obscure. Herein, we …

Dysregulation of the microbiota-brain axis during long-term exposure to polystyrene nanoplastics in rats and the protective role of dihydrocaffeic acid

W Jiang, C Hu, Y Chen, Y Li, X Sun, H Wu… - Science of The Total …, 2023 - Elsevier
Polystyrene nano-plastics (PS-NPs) can be accumulated in the food chain and can
penetrate biological barriers to affect multiple physiological functions. However, the adverse …

Nanoplastics exposure disrupts circadian rhythm associated with dysfunction of the endolysosomal pathway and autophagy in Caenorhabditis elegans

CW Yu, YC Wu, VHC Liao - Journal of Hazardous Materials, 2023 - Elsevier
Nanoplastics (NPs), an emerging pollutant, have raised great safety concerns due to their
widespread applications and continuous release into the environment, which lead to …

[HTML][HTML] Identification of ceRNA network to explain the mechanism of cognitive dysfunctions induced by PS NPs in mice

C Chu, Y Zhang, Q Liu, Y Pang, Y Niu… - … and Environmental Safety, 2022 - Elsevier
Plastics breaking down of larger plastics into smaller ones (microplastics and nanoplastic)
as potential threats to the ecosystem. Previous studies demonstrate that the central nervous …

Exposure to Polystyrene Nanoplastics Led to Learning and Memory Deficits in Zebrafish by Inducing Oxidative Damage and Aggravating Brain Aging

W Zhou, D Tong, D Tian, Y Yu, L Huang… - Advanced …, 2023 - Wiley Online Library
Nanoplastics (NPs) may pass through the blood–brain barrier, giving rise to serious
concerns about their potential toxicity to the brain. In this study, the effects of NPs exposure …

[HTML][HTML] Polystyrene micro-and nanoparticles exposure induced anxiety-like behaviors, gut microbiota dysbiosis and metabolism disorder in adult mice

X Chen, L Xu, Q Chen, S Su, J Zhuang… - … and Environmental Safety, 2023 - Elsevier
Plastics have been proven to be a potential threat to the ecosystem, and their toxicity
mechanism is still uncertain. In the ecological environment, plastics can be degraded into …

[HTML][HTML] Oxidized/unmodified-polyethylene microplastics neurotoxicity in mice: Perspective from microbiota-gut-brain axis

J Wang, Y Yang, Y Shi, L Wei, L Gao, M Liu - Environment International, 2024 - Elsevier
Microplastics (MPs) are inevitably oxidized in the environment, and their potential toxicity to
organisms has attracted wide attention. However, the neurotoxicity and mechanism of …

Photoaged Nanopolystyrene Affects Neurotransmission to Induce Transgenerational Neurotoxicity in Caenorhabditis elegans

H Chen, Y Gu, S Tan, X Chen, Y Jiang… - Environmental …, 2024 - ACS Publications
Nanopolystyrene (NPS), a frequently employed nanoplastic, is an emerging environmental
contaminant known to cause neurotoxicity in various organisms. However, the potential for …

Recent progress and future directions of the research on nanoplastic-induced neurotoxicity

SW Han, J Choi, KY Ryu - Neural regeneration research, 2024 - journals.lww.com
Many types of plastic products, including polystyrene, have long been used in commercial
and industrial applications. Microplastics and nanoplastics, plastic particles derived from …