Comparative transcriptomics reveals human-specific cortical features
The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …
cellular substrates are poorly understood. We used comparative single-nucleus …
Spatiotemporal transcriptomic divergence across human and macaque brain development
INTRODUCTION Improved understanding of how the developing human nervous system
differs from that of closely related nonhuman primates is fundamental for teasing out human …
differs from that of closely related nonhuman primates is fundamental for teasing out human …
Transcriptomic diversity of cell types across the adult human brain
The human brain directs complex behaviors, ranging from fine motor skills to abstract
intelligence, but the diversity of cell types that support these skills has not been fully …
intelligence, but the diversity of cell types that support these skills has not been fully …
Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques
Z He, D Han, O Efimova, P Guijarro, Q Yu… - Nature …, 2017 - nature.com
While human cognitive abilities are clearly unique, underlying changes in brain organization
and function remain unresolved. Here we characterized the transcriptome of the cortical …
and function remain unresolved. Here we characterized the transcriptome of the cortical …
Transcriptomic cytoarchitecture reveals principles of human neocortex organization
NL Jorstad, J Close, N Johansen, AM Yanny… - Science, 2023 - science.org
Variation in cytoarchitecture is the basis for the histological definition of cortical areas. We
used single cell transcriptomics and performed cellular characterization of the human cortex …
used single cell transcriptomics and performed cellular characterization of the human cortex …
Molecular and cellular reorganization of neural circuits in the human lineage
To better understand the molecular and cellular differences in brain organization between
human and nonhuman primates, we performed transcriptome sequencing of 16 regions of …
human and nonhuman primates, we performed transcriptome sequencing of 16 regions of …
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
The mammalian cerebral cortex supports cognitive functions such as sensorimotor
integration, memory, and social behaviors. Normal brain function relies on a diverse set of …
integration, memory, and social behaviors. Normal brain function relies on a diverse set of …
Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH
The human cerebral cortex has tremendous cellular diversity. How different cell types are
organized in the human cortex and how cellular organization varies across species remain …
organized in the human cortex and how cellular organization varies across species remain …
[HTML][HTML] Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution
Enhanced cognitive function in humans is hypothesized to result from cortical expansion
and increased cellular diversity. However, the mechanisms that drive these phenotypic …
and increased cellular diversity. However, the mechanisms that drive these phenotypic …
The genetic architecture of the human cerebral cortex
KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …
Variations in human cortical surface area and thickness are associated with neurological …