Comparative transcriptomics reveals human-specific cortical features

NL Jorstad, JHT Song, D Exposito-Alonso, H Suresh… - Science, 2023 - science.org
The cognitive abilities of humans are distinctive among primates, but their molecular and
cellular substrates are poorly understood. We used comparative single-nucleus …

Spatiotemporal transcriptomic divergence across human and macaque brain development

Y Zhu, AMM Sousa, T Gao, M Skarica, M Li, G Santpere… - Science, 2018 - science.org
INTRODUCTION Improved understanding of how the developing human nervous system
differs from that of closely related nonhuman primates is fundamental for teasing out human …

Transcriptomic diversity of cell types across the adult human brain

K Siletti, R Hodge, A Mossi Albiach, KW Lee, SL Ding… - Science, 2023 - science.org
The human brain directs complex behaviors, ranging from fine motor skills to abstract
intelligence, but the diversity of cell types that support these skills has not been fully …

Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques

Z He, D Han, O Efimova, P Guijarro, Q Yu… - Nature …, 2017 - nature.com
While human cognitive abilities are clearly unique, underlying changes in brain organization
and function remain unresolved. Here we characterized the transcriptome of the cortical …

Transcriptomic cytoarchitecture reveals principles of human neocortex organization

NL Jorstad, J Close, N Johansen, AM Yanny… - Science, 2023 - science.org
Variation in cytoarchitecture is the basis for the histological definition of cortical areas. We
used single cell transcriptomics and performed cellular characterization of the human cortex …

Molecular and cellular reorganization of neural circuits in the human lineage

AMM Sousa, Y Zhu, MA Raghanti, RR Kitchen… - Science, 2017 - science.org
To better understand the molecular and cellular differences in brain organization between
human and nonhuman primates, we performed transcriptome sequencing of 16 regions of …

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

A Zeisel, AB Muñoz-Manchado, S Codeluppi… - Science, 2015 - science.org
The mammalian cerebral cortex supports cognitive functions such as sensorimotor
integration, memory, and social behaviors. Normal brain function relies on a diverse set of …

Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH

R Fang, C Xia, JL Close, M Zhang, J He, Z Huang… - Science, 2022 - science.org
The human cerebral cortex has tremendous cellular diversity. How different cell types are
organized in the human cortex and how cellular organization varies across species remain …

[HTML][HTML] Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution

H Suresh, M Crow, N Jorstad, R Hodge… - Nature Ecology & …, 2023 - nature.com
Enhanced cognitive function in humans is hypothesized to result from cortical expansion
and increased cellular diversity. However, the mechanisms that drive these phenotypic …

The genetic architecture of the human cerebral cortex

KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …