Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures

G Kai, H Xu, C Zhou, P Liao, J Xiao, X Luo, L You… - Metabolic …, 2011 - Elsevier
Tanshinone is a group of active diterpenes widely used in treatment of cardiovascular
diseases. Here, we report the introduction of genes encoding 3-hydroxy-3-methylglutaryl …

Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering

M Shi, X Luo, G Ju, L Li, S Huang, T Zhang… - Journal of agricultural …, 2016 - ACS Publications
Tanshinones are health-promoting diterpenoids found in Salvia miltiorrhiza and have wide
applications. Here, SmGGPPS (geranylgeranyl diphosphate synthase) and SmDXSII (1 …

Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA …

M Shi, X Luo, G Ju, X Yu, X Hao, Q Huang… - Functional & integrative …, 2014 - Springer
Tanshinone is widely used for treatment of cardio-cerebrovascular diseases with increasing
demand. Herein, key enzyme genes SmHMGR (3-hydroxy-3-methylglutaryl CoA reductase) …

Molecular mechanism of elicitor-induced tanshinone accumulation in Salvia miltiorrhiza hairy root cultures

G Kai, P Liao, H Xu, J Wang, C Zhou, W Zhou… - Acta Physiologiae …, 2012 - Springer
To develop an optimal bioprocess for the production of tanshinone which is mainly used for
the treatment of cardiocerebral vascular disease, the tanshinone biosynthetic pathway …

Effects of methyl jasmonate and salicylic acid on tanshinone production and biosynthetic gene expression in transgenic Salvia miltiorrhiza hairy roots

X Hao, M Shi, L Cui, C Xu, Y Zhang… - Biotechnology and …, 2015 - Wiley Online Library
Tanshinone is a group of active diterpenes, which are widely used in the treatment of
cardiovascular disease. In this study, methyl jasmonate (MJ) and salicylic acid (SA) were …

The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza

XH Ma, Y Ma, JF Tang, YL He, YC Liu, XJ Ma, Y Shen… - Molecules, 2015 - mdpi.com
Secondary metabolites from plants play key roles in human medicine and chemical
industries. Due to limited accumulation of secondary metabolites in plants and their …

Different Roles of the Mevalonate and Methylerythritol Phosphate Pathways in Cell Growth and Tanshinone Production of Salvia miltiorrhiza Hairy Roots

D Yang, X Du, X Liang, R Han, Z Liang, Y Liu, F Liu… - PloS one, 2012 - journals.plos.org
Salvia miltiorrhiza has been widely used in the treatment of coronary heart disease.
Tanshinones, a group of diterpenoids are the main active ingredients in S. miltiorrhiza. Two …

Comprehensive transcriptome profiling of Salvia miltiorrhiza for discovery of genes associated with the biosynthesis of tanshinones and phenolic acids

W Zhou, Q Huang, X Wu, Z Zhou, M Ding, M Shi… - Scientific Reports, 2017 - nature.com
Tanshinones and phenolic acids are crucial bioactive compounds biosynthesized in Salvia
miltiorrhiza. Methyl jasmonate (MeJA) is an effective elicitor to enhance the production of …

Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures

JW Wang, JY Wu - Applied Microbiology and Biotechnology, 2010 - Springer
Abstract Salvia miltiorrhiza Bunge (Lamiaceae) root, generally called Danshen, is an
important herb in Chinese medicine widely used for treatment of cardiovascular diseases …

Endophytic fungus Cladosporium tenuissimum DF11, an efficient inducer of tanshinone biosynthesis in Salvia miltiorrhiza roots

H Chen, J Chen, Y Qi, S Chu, Y Ma, L Xu, S Lv… - Phytochemistry, 2022 - Elsevier
Salvia miltiorrhiza is a traditional medicinal plant mainly used for cardiovascular and
cerebrovascular disease treatment. Tanshinones are the main bioactive constituents of S …