Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures
Tanshinone is a group of active diterpenes widely used in treatment of cardiovascular
diseases. Here, we report the introduction of genes encoding 3-hydroxy-3-methylglutaryl …
diseases. Here, we report the introduction of genes encoding 3-hydroxy-3-methylglutaryl …
Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering
M Shi, X Luo, G Ju, L Li, S Huang, T Zhang… - Journal of agricultural …, 2016 - ACS Publications
Tanshinones are health-promoting diterpenoids found in Salvia miltiorrhiza and have wide
applications. Here, SmGGPPS (geranylgeranyl diphosphate synthase) and SmDXSII (1 …
applications. Here, SmGGPPS (geranylgeranyl diphosphate synthase) and SmDXSII (1 …
Increased accumulation of the cardio-cerebrovascular disease treatment drug tanshinone in Salvia miltiorrhiza hairy roots by the enzymes 3-hydroxy-3-methylglutaryl CoA …
M Shi, X Luo, G Ju, X Yu, X Hao, Q Huang… - Functional & integrative …, 2014 - Springer
Tanshinone is widely used for treatment of cardio-cerebrovascular diseases with increasing
demand. Herein, key enzyme genes SmHMGR (3-hydroxy-3-methylglutaryl CoA reductase) …
demand. Herein, key enzyme genes SmHMGR (3-hydroxy-3-methylglutaryl CoA reductase) …
Molecular mechanism of elicitor-induced tanshinone accumulation in Salvia miltiorrhiza hairy root cultures
To develop an optimal bioprocess for the production of tanshinone which is mainly used for
the treatment of cardiocerebral vascular disease, the tanshinone biosynthetic pathway …
the treatment of cardiocerebral vascular disease, the tanshinone biosynthetic pathway …
Effects of methyl jasmonate and salicylic acid on tanshinone production and biosynthetic gene expression in transgenic Salvia miltiorrhiza hairy roots
X Hao, M Shi, L Cui, C Xu, Y Zhang… - Biotechnology and …, 2015 - Wiley Online Library
Tanshinone is a group of active diterpenes, which are widely used in the treatment of
cardiovascular disease. In this study, methyl jasmonate (MJ) and salicylic acid (SA) were …
cardiovascular disease. In this study, methyl jasmonate (MJ) and salicylic acid (SA) were …
The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza
XH Ma, Y Ma, JF Tang, YL He, YC Liu, XJ Ma, Y Shen… - Molecules, 2015 - mdpi.com
Secondary metabolites from plants play key roles in human medicine and chemical
industries. Due to limited accumulation of secondary metabolites in plants and their …
industries. Due to limited accumulation of secondary metabolites in plants and their …
Different Roles of the Mevalonate and Methylerythritol Phosphate Pathways in Cell Growth and Tanshinone Production of Salvia miltiorrhiza Hairy Roots
D Yang, X Du, X Liang, R Han, Z Liang, Y Liu, F Liu… - PloS one, 2012 - journals.plos.org
Salvia miltiorrhiza has been widely used in the treatment of coronary heart disease.
Tanshinones, a group of diterpenoids are the main active ingredients in S. miltiorrhiza. Two …
Tanshinones, a group of diterpenoids are the main active ingredients in S. miltiorrhiza. Two …
Comprehensive transcriptome profiling of Salvia miltiorrhiza for discovery of genes associated with the biosynthesis of tanshinones and phenolic acids
W Zhou, Q Huang, X Wu, Z Zhou, M Ding, M Shi… - Scientific Reports, 2017 - nature.com
Tanshinones and phenolic acids are crucial bioactive compounds biosynthesized in Salvia
miltiorrhiza. Methyl jasmonate (MeJA) is an effective elicitor to enhance the production of …
miltiorrhiza. Methyl jasmonate (MeJA) is an effective elicitor to enhance the production of …
Tanshinone biosynthesis in Salvia miltiorrhiza and production in plant tissue cultures
Abstract Salvia miltiorrhiza Bunge (Lamiaceae) root, generally called Danshen, is an
important herb in Chinese medicine widely used for treatment of cardiovascular diseases …
important herb in Chinese medicine widely used for treatment of cardiovascular diseases …
Endophytic fungus Cladosporium tenuissimum DF11, an efficient inducer of tanshinone biosynthesis in Salvia miltiorrhiza roots
H Chen, J Chen, Y Qi, S Chu, Y Ma, L Xu, S Lv… - Phytochemistry, 2022 - Elsevier
Salvia miltiorrhiza is a traditional medicinal plant mainly used for cardiovascular and
cerebrovascular disease treatment. Tanshinones are the main bioactive constituents of S …
cerebrovascular disease treatment. Tanshinones are the main bioactive constituents of S …