Whole organ engineering: approaches, challenges, and future directions

S Sohn, MV Buskirk, MJ Buckenmeyer, R Londono… - Applied Sciences, 2020 - mdpi.com
Featured Application The specific application of this review article is for the advancement of
commercially translatable technologies in the field of whole organ engineering. Abstract End …

Tissue engineering: toward a new era of medicine

A Shafiee, A Atala - Annual review of medicine, 2017 - annualreviews.org
The goal of tissue engineering is to mitigate the critical shortage of donor organs via in vitro
fabrication of functional biological structures. Tissue engineering is one of the most …

Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds

SF Badylak, D Taylor, K Uygun - Annual review of biomedical …, 2011 - annualreviews.org
The definitive treatment for end-stage organ failure is orthotopic transplantation. However,
the demand for transplantation far exceeds the number of available donor organs. A …

State-of-the-art tissue engineering: from tissue engineering to organ building

SJ Shieh, JP Vacanti - Surgery, 2005 - surgjournal.com
TISSUE LOSS OR END-STAGE ORGAN FAILURE caused by injury or other types of
damage is one of the most devastating and costly problems in human health care. Surgical …

Highlights on advancing frontiers in tissue engineering

N Ashammakhi, A GhavamiNejad, R Tutar… - … Engineering Part B …, 2022 - liebertpub.com
The field of tissue engineering continues to advance, sometimes in exponential leaps
forward, but also sometimes at a rate that does not fulfill the promise that the field imagined a …

Perspectives on whole-organ assembly: moving toward transplantation on demand

A Soto-Gutierrez, JA Wertheim, HC Ott… - The Journal of …, 2012 - Am Soc Clin Investig
There is an ever-growing demand for transplantable organs to replace acute and chronically
damaged tissues. This demand cannot be met by the currently available donor organs …

Chasing the paradigm: clinical translation of 25 years of tissue engineering

T Hoffman, A Khademhosseini… - Tissue Engineering Part …, 2019 - liebertpub.com
In the past 25 years, the tissue engineering field has made incredible strides in developing
tangible therapies for patients in need. Applications of the tissue engineering paradigm …

Comparison of methods for whole-organ decellularization in tissue engineering of bioartificial organs

M He, A Callanan - Tissue Engineering Part B: Reviews, 2013 - liebertpub.com
Organ transplantation is now a well-established procedure for the treatment of end-stage
organ failure due to various causes, but is a victim of its own success in that there is a …

Concise review: organ engineering: design, technology, and integration

G Kaushik, J Leijten, A Khademhosseini - Stem Cells, 2017 - academic.oup.com
Engineering complex tissues and whole organs has the potential to dramatically impact
translational medicine in several avenues. Organ engineering is a discipline that integrates …

Design approaches for generating organ constructs

Y Xia, JCI Belmonte - Cell Stem Cell, 2019 - cell.com
Organ constructs are organ-like structures grown in vitro or in vivo that harbor the
components, architecture, and function of in vivo organs, in part or in toto. The convergence …