Subversion of the endocytic and secretory pathways by bacterial effector proteins

MM Weber, R Faris - Frontiers in cell and developmental biology, 2018 - frontiersin.org
Intracellular bacteria have developed numerous strategies to hijack host vesicular trafficking
pathways to form their unique replicative niches. To promote intracellular replication, the …

Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors

SW Hicks, JE Galán - Nature Reviews Microbiology, 2013 - nature.com
Several bacterial species have evolved specialized secretion systems to deliver bacterial
effector proteins into eukaryotic cells. These effectors have the capacity to modulate host cell …

Bacterial effector interplay: a new way to view effector function

SR Shames, BB Finlay - Trends in microbiology, 2012 - cell.com
Bacterial pathogens are dependent on virulence factors to efficiently colonize and propagate
within their hosts. Many Gram-negative bacterial pathogens rely on specialized …

Modification of bacterial effector proteins inside eukaryotic host cells

CM Popa, M Tabuchi, M Valls - Frontiers in cellular and infection …, 2016 - frontiersin.org
Pathogenic bacteria manipulate their hosts by delivering a number of virulence proteins-
called effectors-directly into the plant or animal cells. Recent findings have shown that such …

Secretion systems used by bacteria to subvert host functions

C Rapisarda, R Fronzes - Current issues in molecular biology, 2018 - mdpi.com
In this review we examine the use of secretion systems by bacteria to subvert host functions.
Bacteria have evolved multiple systems to interact with and overcome their eukaryotic host …

Revealing the mechanisms of membrane protein export by virulence-associated bacterial secretion systems

L Krampen, S Malmsheimer, I Grin, T Trunk… - Nature …, 2018 - nature.com
Many bacteria export effector proteins fulfilling their function in membranes of a eukaryotic
host. These effector membrane proteins appear to contain signals for two incompatible …

Common themes in the design and function of bacterial effectors

JE Galán - Cell host & microbe, 2009 - cell.com
Central to the biology of many pathogenic bacteria are a number of specialized machines,
known as type III, type IV, or type VI protein secretion systems. These machines have …

How bacteria subvert animal cell structure and function

A Jimenez, D Chen, NM Alto - Annual review of cell and …, 2016 - annualreviews.org
Bacterial pathogens encode a wide variety of effectors and toxins that hijack host cell
structure and function. Of particular importance are virulence factors that target actin …

Interactions of bacterial effector proteins with host proteins

S Mattoo, YM Lee, JE Dixon - Current opinion in immunology, 2007 - Elsevier
Pathogenic bacteria have evolved several clever survival strategies for manipulating host
cell signaling pathways to establish beneficial replicative niches within the host. Recent …

Virulence-associated type III secretion systems in Gram-negative bacteria

SV Pais, E Kim, S Wagner - Microbiology, 2023 - microbiologyresearch.org
Virulence-associated bacterial type III secretion systems are multiprotein molecular
machines that promote the pathogenicity of bacteria towards eukaryotic host cells. These …