Peptides carry important functions in normal physiological and pathophysiological
processes and can serve as clinically useful biomarkers. Given the ability to diffuse …

Extensive effort has been devoted to the discovery, development, and validation of
biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the …

BACKGROUND For many years, basic and clinical researchers have taken advantage of the
analytical sensitivity and specificity afforded by mass spectrometry in the measurement of …

Peptidomics techniques have allowed the identification of thousands of peptides that are
derived from proteins in body fluids, despite the considerable challenges behind sample …

The general awareness of the importance of peptides in physiology and pathophysiology
has increased strongly over the last few years. With worldwide progress in the analysis of …

Endogenous peptides, such as neuropeptides and peptide hormones, play important roles
in intercellular communication, can provide information on physiology, and are potential …

The study of pharmacologically active peptides is central to the understanding of disease
and development of novel therapies. It would be advantageous to monitor the fate of …

Naturally occurring peptides, including growth factors, hormones, and neurotransmitters,
represent an important class of biomolecules and have crucial roles in human physiology …

Background: In the past few decades, with the upsurge of various deadly diseases,
development of accurate diagnostic methods is inevitable for maintaining good health …

The low molecular weight (LMW;< 10 kDa)* plasma peptidome has been considered a
source of useful diagnostic biomarkers and potentially therapeutic molecules, as it contains …