[HTML][HTML] Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration

JJ Neher, U Neniskyte, GC Brown - Frontiers in pharmacology, 2012 - frontiersin.org
Microglial phagocytosis of dead or dying neurons can be beneficial by preventing the
release of damaging and/or pro-inflammatory intracellular components. However, there is …

Microglial phagocytosis of live neurons

GC Brown, JJ Neher - Nature Reviews Neuroscience, 2014 - nature.com
Microglia, the brain's professional phagocytes, can remove dead and dying neurons as well
as synapses and the processes of live neurons. However, we and others have recently …

[HTML][HTML] Clearing the corpses: regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain

I Diaz-Aparicio, S Beccari, O Abiega… - Neural regeneration …, 2016 - journals.lww.com
Apoptosis is a widespread phenomenon that occurs in the brain in both physiological and
pathological conditions. Dead cells must be quickly removed to avoid the further toxic effects …

Cell death by phagocytosis

GC Brown - Nature Reviews Immunology, 2024 - nature.com
Cells can die as a consequence of being phagocytosed by other cells—a form of cell death
that has been called phagotrophy, cell cannibalism, programmed cell removal and primary …

How brain 'cleaners' fail: mechanisms and therapeutic value of microglial phagocytosis in Alzheimer's disease

J Ni, Z Xie, Z Quan, J Meng, H Qing - Glia, 2024 - Wiley Online Library
Microglia are the resident phagocytes of the brain, where they primarily function in the
clearance of dead cells and the removal of un‐or misfolded proteins. The impaired activity of …

Microglial phagocytosis in aging and Alzheimer's disease

E Gabandé‐Rodríguez, L Keane… - Journal of …, 2020 - Wiley Online Library
Microglia are the innate immune cells of the brain, which maintain homeostasis by
constantly scanning and surveying the environment with their highly ramified processes. In …

Central nervous system diseases related to pathological microglial phagocytosis

K Wang, J Li, Y Zhang, Y Huang… - CNS Neuroscience …, 2021 - Wiley Online Library
Microglia are important phagocytes of the central nervous system (CNS). They play an
important role in protecting the CNS by clearing necrotic tissue and apoptotic cells in many …

Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death

JJ Neher, U Neniskyte, JW Zhao… - The Journal of …, 2011 - journals.aai.org
It is well-known that dead and dying neurons are quickly removed through phagocytosis by
the brain's macrophages, the microglia. Therefore, neuronal loss during brain inflammation …

[HTML][HTML] Microglial phagocytosis and its regulation: a therapeutic target in Parkinson's disease?

E Janda, L Boi, AR Carta - Frontiers in molecular neuroscience, 2018 - frontiersin.org
The role of phagocytosis in the neuroprotective function of microglia has been appreciated
for a long time, but only more recently a dysregulation of this process has been recognized …

Phagocytic astrocytes: emerging from the shadows of microglia

H Konishi, S Koizumi, H Kiyama - Glia, 2022 - Wiley Online Library
Elimination of dead or live cells take place in both a healthy and diseased central nervous
system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance …