Ischemic depolarizing events, such as repetitive spontaneous periinfarct spreading
depolarizations (PIDs), expand the infarct size after experimental middle cerebral artery …

S88 Stroke June 2013 or injury depolarizations. 19, 20 Interestingly, the vasoconstrictive
components are most conspicuous during the first spreading depression in naïve tissue, and …

Peri-infarct depolarizations (PIDs) are seemingly spontaneous spreading depression-like
waves that negatively impact tissue outcome in both experimental and human stroke …

In focal cerebral ischemia, peri-infarct depolarizations (PIDs) cause an expansion of core-
infarcted tissue into adjacent penumbral regions of reversible injury and have been shown …

Background and Purpose—Spreading depression (SD)-like depolarizations may augment
neuronal damage in neurovascular disorders such as stroke and traumatic brain injury …

Cortical spreading depression (CSD) evokes a large cerebral blood flow (CBF) increase in
normal rat brain. In contrast, in focal ischemic penumbra, CSD-like periinfarct …

In the light of accumulating evidence for the occurrence of spontaneous cortical spreading
depression and peri-infarct depolarizations in the human brain injured by trauma or …

This study was undertaken to test whether transient depolarizations occurring in periinfarct
regions are important in contributing to infarct spread and maturation. Following middle …

Stroke is one of the most common diseases and a leading cause of death and disability.
Cessation of cerebral blood flow (CBF) leads to cell death in the infarct core, but tissue …

In the surroundings of focal ischemic lesions, repetitive spreading depression (SD)-like
depolarizations occur. These depolarizations are triggered by the anoxic release of …