Specific gene expression involves the binding of natural ligands to the DNA base pairs.
Among the compounds rationally designed for artificial regulation of gene expression …

Oligonucleotides offer enormous potential for manipulating gene function in cells and, as
such, constitute a promising new class of pharmaceutical agents. Oligonucleotides that form …

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that
can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a …

An outgrowth of classic nucleic acid interaction studies, oligonucleotide-directed triple helix
formation is a unique method for creating highly specific chemical ligands that recognize …

Nucleic acids can be selectively recognized by a large number of natural and synthetic
ligands. Oligonucleotides provide the highest specificity of recognition. They can bind to a …

The formation of intermolecular DNA triple helices offers the possibility of designing
compounds with extensive sequence recognition properties which may be useful as …

Oligonucleotides can be used to control gene expression according to several strategies. In
the antisense approach the oligonucleotide is targeted to a messenger RNA, thereby …

Recognition of B-DNA by oligonucleotides that form triple helices is a unique method to
specifically recognize sequences of double-stranded DNA. Recently, some significant …

Triplex-forming oligonucleotides (TFOs) have gained prominence in the recent years
because of their potential applications in antigene therapy. In particular they have been …

We demonstrate that ligand binding can be used to induce the formation of triplex structures
that would not otherwise form. Specifically, we show that binding of berenil or 4', 6-diamidino …