Neurodevelopmental effects of maternal folic acid supplementation: A systematic review and meta-analysis

H Chen, L Qin, R Gao, X Jin, K Cheng… - Critical Reviews in …, 2023 - Taylor & Francis
Folic acid, a water-soluble vitamin B nutrient, plays an important role not only in maintaining
a healthy pregnancy but also in offspring brain development and function, however, it …

Maternal oversupplementation with folic acid and its impact on neurodevelopment of offspring

LK Murray, MJ Smith, NM Jadavji - Nutrition reviews, 2018 - academic.oup.com
Folic acid, a B vitamin, is vital for early neurodevelopment and is well known for its protective
effect against neural tube defects. Various national health agencies worldwide recommend …

[HTML][HTML] New perspective on impact of folic acid supplementation during pregnancy on neurodevelopment/autism in the offspring children–a systematic review

Y Gao, C Sheng, R Xie, W Sun, E Asztalos… - PloS one, 2016 - journals.plos.org
It has been conclusively established that folic acid supplementation prior to and during early
pregnancy (up to 12 weeks of gestation) can prevent neural tube defects (NTDs). We …

[HTML][HTML] The importance of maternal folate status for brain development and function of offspring

EFG Naninck, PC Stijger, EM Brouwer-Brolsma - Advances in nutrition, 2019 - Elsevier
The importance of an adequate periconceptional maternal folate status to prevent fetal
neural tube defects has been well demonstrated and resulted in the recommendation for …

Review and meta‐analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development

L Iglesias Vazquez, J Canals, V Arija - Acta Paediatrica, 2019 - Wiley Online Library
Aim The impact of prenatal folic acid on children's neurodevelopment and the risk of autism
spectrum disorder (ASD) remain unclear and this review and meta‐analysis aimed to …

[HTML][HTML] Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4–5 y of age: the prospective birth cohort Infancia y …

D Valera-Gran, EM Navarrete-Munoz… - The American journal of …, 2017 - Elsevier
Background The benefits of the use of folic acid supplements (FASs) during the
periconception period to prevent neural tube defects and to ensure normal brain …

Folic acid supplements during pregnancy and child psychomotor development after the first year of life

D Valera-Gran, MG de la Hera… - JAMA …, 2014 - jamanetwork.com
Importance Folate intake during pregnancy has been associated with improved
neuropsychological development in children, although the effects of high dosages of folic …

[HTML][HTML] Prenatal folic acid supplements and offspring's autism spectrum disorder: a meta-analysis and meta-regression

X Liu, M Zou, C Sun, L Wu, WX Chen - Journal of autism and …, 2022 - Springer
We systematically reviewed the evidence on the association between maternal folic acid
supplementation and the risk of offspring's autism spectrum disorders (ASD). A total of 10 …

Maternal folate nutrition and offspring health: evidence and current controversies

A Caffrey, H McNulty, RE Irwin, CP Walsh… - Proceedings of the …, 2019 - cambridge.org
Periconceptional folic acid (FA) is known to have a protective effect in the prevention of
neural tube defects (NTD), leading to global recommendations for FA supplementation …

Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: the mother–child cohort 'Rhea'study in Crete …

L Chatzi, E Papadopoulou, K Koutra… - Public health …, 2012 - cambridge.org
ObjectiveTo investigate whether high doses of folic acid supplementation in early pregnancy
are associated with child neurodevelopment at 18 months of age. DesignThe study uses …