The serrated neoplasia pathway constitutes an “alternative route” to colorectal cancer
(CRC), and sessile serrated lesions with dysplasia (SSLDs) are an intermediate step …

Sessile serrated adenoma/polyps (SSA/Ps) are early precursor lesions in the serrated
neoplasia pathway, which results in colorectal carcinomas with BRAF mutations, methylation …

The 2019 World Health Organization (WHO) Classification of Tumours of the Digestive
System (5th edition) introduced the term “sessile serrated lesion”(SSL) to replace the term …

The concept of serrated colorectal neoplasia and a serrated pathway to colorectal cancer
(CRC) is relatively new and continuing to evolve, but it has become highly relevant to …

Objective The serrated neoplasia pathway accounts for up to 30% of all sporadic colorectal
cancers (CRCs). Sessile serrated adenomas/polyps (SSA/Ps) with cytological dysplasia …

Until 2010, colorectal serrated lesions were generally considered as harmless lesions and
reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However …

Sessile serrated adenoma/polyps (SSA/Ps) are early precursor lesions in the serrated
neoplasia pathway, which results in BRAF‐mutated colorectal carcinomas with not only high …

It is currently known that colorectal cancers (CRC) arise from 3 different pathways: the
adenoma to carcinoma chromosomal instability pathway (50%-70%); the mutator “Lynch …

Identification of the serrated neoplasia pathway has improved our understanding of the
pathogenesis of colorectal cancer (CRC). Insights include an increased recognition of the …

Serrated polyps are important contributors to the burden of colorectal cancers (CRC). These
lesions were once considered to have no malignant potential, but currently up to 30% of all …