Reconstituted dry powder formulations of ZnO-adjuvanted ovalbumin induce equivalent antigen specific antibodies but lower T cell responses than ovalbumin …

M Hellfritzsch, D Christensen, C Foged… - International Journal of …, 2023 - Elsevier
Most licensed human vaccines are based on liquid dosage forms but have poor storage
stability and require continuous and expensive cold-chain storage. In contrast, the use of …

Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb/c mice

R Roy, S Kumar, AK Verma, A Sharma… - International …, 2014 - academic.oup.com
Zinc oxide nanoparticles (ZNPs) have been used in dietary supplements and may cause an
immunomodulatory effect. The present study investigated the effect of ZNPs on antigen …

Hollow ZnO Nanospheres Enhance Anticancer Immunity by Promoting CD4+ and CD8+ T Cell Populations In Vivo

X Wang, X Li, A Ito, Y Sogo, Y Watanabe, NM Tsuji - Small, 2017 - Wiley Online Library
Appropriate adjuvant aiding in generating robust anticancer immunity is crucial for cancer
immunotherapy. Herein, hollow ZnO (HZnO) nanospheres are synthesized by a facile …

Effect of antigen structure in subunit vaccine nanoparticles on humoral immune responses

J Park, JA Champion - ACS Biomaterials Science & Engineering, 2023 - ACS Publications
Subunit vaccines offer numerous attractive features, including good safety profiles and well-
defined components with highly characterized properties because they do not contain whole …

OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis

N Yanase, H Toyota, K Hata, S Yagyu, T Seki… - Vaccine, 2014 - Elsevier
There is an urgent requirement for a novel vaccine that can stimulate immune responses
without unwanted toxicity, including IgE elevation. We examined whether antigen ovalbumin …

Colloidal characteristics and formulation of pure protein particulate vaccines

PJ White, P Hickey, L Sze Tu, SJ Headey… - Journal of Pharmacy …, 2012 - academic.oup.com
Objectives We recently reported that dense gas processing of the protein ovalbumin (OVA)
resulted in the formation of particles that were insoluble in water and which retained their …

Mesoporous ZnO nanocapsules for the induction of enhanced antigen-specific immunological responses

S Afroz, H Medhi, S Maity, G Minhas, S Battu… - Nanoscale, 2017 - pubs.rsc.org
The application of nanotechnology in vaccinology has fuelled rapid advancement towards
the design and development of nanovaccines. Nanoparticles have been found to enhance …

Comparative molecular immunological activity of physiological metal oxide nanoparticle and its anticancer peptide and rna complexes

RK DeLong, J Comer, EN Mathew, M Jaberi-Douraki - Nanomaterials, 2019 - mdpi.com
Currently, there is a great interest in nanoparticle-based vaccine delivery. Recent studies
suggest that nanoparticles when introduced into the biological milieu are not simply passive …

Development of a novel vaccine delivery system based on Gantrez nanoparticles

S Gómez, C Gamazo, BS Roman… - … of nanoscience and …, 2006 - ingentaconnect.com
The adjuvant capacity of a novel vaccine vector “Gantrez-nanoparticles”(NP) towards coated
or encapsulated ovalbumin (OVA) was investigated. OVA nanoparticles were prepared by a …

Lignin nanoparticles as a promising vaccine adjuvant and delivery system for ovalbumin

MS Alqahtani, M Kazi, MZ Ahmad, R Syed… - International Journal of …, 2020 - Elsevier
Vaccination is the most effective strategy of preventing and treating infectious diseases and
the most significant issue in the development of potent vaccines is the sufficient …