m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity
N6-methyladenosine (m6A) modification is dynamically regulated by “writer” and “eraser”
enzymes. m6A “writers” have been shown to ensure the homeostasis of CD4+ T cells, but …
enzymes. m6A “writers” have been shown to ensure the homeostasis of CD4+ T cells, but …
Implications of m6A modification in autoimmune disorders
A Paramasivam, JV Priyadharsini… - Cellular & molecular …, 2020 - nature.com
N6-Methyladenosine (m6A) is the most common and abundant modification of RNA
molecules, including mRNAs, microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) …
molecules, including mRNAs, microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) …
[HTML][HTML] Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
Abstract N6-methyladenosine (m6A) modification plays important roles in various cellular
responses by regulating mRNA biology. However, how m6A modification is involved in …
responses by regulating mRNA biology. However, how m6A modification is involved in …
m6A modifications regulate intestinal immunity and rotavirus infection
A Wang, W Tao, J Tong, J Gao, J Wang, G Hou, C Qian… - Elife, 2022 - elifesciences.org
Abstract N6-methyladenosine (m6A) is an abundant mRNA modification and affects many
biological processes. However, how m6A levels are regulated during physiological or …
biological processes. However, how m6A levels are regulated during physiological or …
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells
γδ T cells are an abundant T cell population at the mucosa and are important in providing
immune surveillance as well as maintaining tissue homeostasis. However, despite γδ T …
immune surveillance as well as maintaining tissue homeostasis. However, despite γδ T …
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity
N 6-methyladenosine (m6A) is the most prevalent posttranscriptional modification on RNA.
NK cells are the predominant innate lymphoid cells that mediate antiviral and antitumor …
NK cells are the predominant innate lymphoid cells that mediate antiviral and antitumor …
Interplay of m6A and H3K27 trimethylation restrains inflammation during bacterial infection
C Wu, W Chen, J He, S Jin, Y Liu, Y Yi, Z Gao… - Science …, 2020 - science.org
While N 6-methyladenosine (m6A) is the most prevalent modification of eukaryotic
messenger RNA (mRNA) involved in various cellular responses, its role in modulating …
messenger RNA (mRNA) involved in various cellular responses, its role in modulating …
[HTML][HTML] m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration
Neutrophil migration into the site of infection is necessary for antibacterial innate defense,
whereas impaired neutrophil migration may result in excessive inflammation and even …
whereas impaired neutrophil migration may result in excessive inflammation and even …
[HTML][HTML] m6A mRNA methylation sustains Treg suppressive functions
N6-methyladenosine (m6A) is the most abundant mRNA chemical modification, and is
modulated by m6A 'writers','erasers' and 'readers' proteins [1-3]. In vitro experiments suggest …
modulated by m6A 'writers','erasers' and 'readers' proteins [1-3]. In vitro experiments suggest …
[HTML][HTML] A broad m6A modification landscape in inflammatory bowel disease
K Nie, J Yi, Y Yang, M Deng, Y Yang… - Frontiers in cell and …, 2022 - frontiersin.org
Background and aims: N6-methyladenosine (m6A) is the most common post-transcriptional
modification on eukaryotic mRNA, affecting mRNA's fate. The role of m6A regulation in …
modification on eukaryotic mRNA, affecting mRNA's fate. The role of m6A regulation in …