Glutathione (GSH) is the most abundant cellular antioxidant. As reactive oxygen species
(ROS) are widely believed to promote aging and age-related diseases, and antioxidants can …

Identification of biologically active natural compounds that promote health and longevity and
understanding how they act, will provide insights into aging and metabolism and strategies …

Aims: To investigate the role of endogenous hydrogen sulfide (H2S) in the control of aging
and healthspan of Caenorhabditis elegans. Results: We show that the model organism, C …

The redox environment in cells and organisms is set by low-molecular mass and protein-
bound thiols, with glutathione (GSH) representing a major intracellular redox buffer. Subtle …

Medicinal benefits of Allium vegetables, such as garlic, have been noted throughout
recorded history, including protection against cancer and cardiovascular disease. We now …

Living longer without simultaneously extending years spent in good health (“health span”) is
an increasing societal burden, demanding new therapeutic strategies. Hydrogen sulfide …

Metabolism is intimately linked to aging. There is a growing number of studies showing that
endogenous metabolites may delay aging and improve healthspan. Through the analysis of …

Reactive oxygen species (ROS) are potentially toxic, but they are also signaling molecules
that modulate aging. Recent observations that ROS can promote longevity have to be …

The cellular proteostasis network integrates the protein folding and clearance machineries
in multiple sub‐cellular compartments of the eukaryotic cell. The endoplasmic reticulum (ER) …

The green tea polyphenol epigallocatechin-3-gallate (EGCG) is widely consumed as a
dietary supplement. Its potential properties include slowing aging and extending lifespan …