Voltage-and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop
Q Xiao, K Yu, P Perez-Cornejo, Y Cui… - Proceedings of the …, 2011 - National Acad Sciences
Ca2+-activated Cl− channels (CaCCs) are exceptionally well adapted to subserve diverse
physiological roles, from epithelial fluid transport to sensory transduction, because their …
physiological roles, from epithelial fluid transport to sensory transduction, because their …
Purified TMEM16A is sufficient to form Ca2+-activated Cl− channels
H Terashima, A Picollo… - Proceedings of the …, 2013 - National Acad Sciences
Ca2+-activated Cl− channels (CaCCs) are key regulators of numerous physiological
functions, ranging from electrolyte secretion in airway epithelia to cellular excitability in …
functions, ranging from electrolyte secretion in airway epithelia to cellular excitability in …
Activation of Ca2+‐activated Cl− channel ANO1 by localized Ca2+ signals
X Jin, S Shah, X Du, H Zhang… - The Journal of …, 2016 - Wiley Online Library
Abstract Ca2+‐activated chloride channels (CaCCs) regulate numerous physiological
processes including epithelial transport, smooth muscle contraction and sensory processing …
processes including epithelial transport, smooth muscle contraction and sensory processing …
Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin
The Ca2+-activated Cl channel anoctamin-1 (Ano1; Tmem16A) plays a variety of
physiological roles, including epithelial fluid secretion. Ano1 is activated by increases in …
physiological roles, including epithelial fluid secretion. Ano1 is activated by increases in …
The sixth transmembrane segment is a major gating component of the TMEM16A calcium-activated chloride channel
Calcium-activated chloride channels (CaCCs) formed by TMEM16A or TMEM16B are
broadly expressed in the nervous system, smooth muscles, exocrine glands, and other …
broadly expressed in the nervous system, smooth muscles, exocrine glands, and other …
TMEM16A confers receptor-activated calcium-dependent chloride conductance
Abstract Calcium (Ca2+)-activated chloride channels are fundamental mediators in
numerous physiological processes including transepithelial secretion, cardiac and neuronal …
numerous physiological processes including transepithelial secretion, cardiac and neuronal …
A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity
TMEM16A forms calcium-activated chloride channels (CaCCs) that regulate physiological
processes such as the secretions of airway epithelia and exocrine glands, the contraction of …
processes such as the secretions of airway epithelia and exocrine glands, the contraction of …
Gating the pore of the calcium-activated chloride channel TMEM16A
AKM Lam, J Rheinberger, C Paulino… - Nature communications, 2021 - nature.com
The binding of cytoplasmic Ca2+ to the anion-selective channel TMEM16A triggers a
conformational change around its binding site that is coupled to the release of a gate at the …
conformational change around its binding site that is coupled to the release of a gate at the …
Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A
AKM Lam, R Dutzler - Elife, 2018 - elifesciences.org
TMEM16A is a ligand-gated anion channel that is activated by intracellular Ca2+. This
channel comprises two independent pores and closely apposed Ca2+ binding sites that are …
channel comprises two independent pores and closely apposed Ca2+ binding sites that are …
Activation and inhibition of TMEM16A calcium-activated chloride channels
Calcium-activated chloride channels (CaCC) encoded by family members of
transmembrane proteins of unknown function 16 (TMEM16) have recently been intensely …
transmembrane proteins of unknown function 16 (TMEM16) have recently been intensely …