It is now well known that oxidative stress promotes lipid peroxidation, protein oxidation,
activation of proteases, fragmentation of DNA and alteration in gene expression for …

Ischemia-reperfusion (I/R) injury is well-known to be associated with impaired cardiac
function, massive arrhythmias, marked alterations in cardiac metabolism and irreversible …

Although heart failure due to a wide variety of pathological stimuli including myocardial
infarction, pressure overload and volume overload is associated with cardiac hypertrophy …

Oxidative stress is a condition in which reactive oxygen species (ROS) or free radicals,
namely O2•–, H2O2, and• OH, are generated extra-or intracellularly and exert toxic effects …

Several studies have revealed varying degrees of changes in sarcoplasmic reticular and
myofibrillar activities, protein content, gene expression and intracellular Ca 2+-handling …

Myocardial failure is associated with increased oxidative stress and abnormal excitation–
contraction coupling characterized by depletion of sarcoplasmic reticulum (SR) Ca2+ stores …

Many experiments have been done to clarify the effects of oxygen free radicals on Ca 2+
homeostasis in the hearts. A burst of oxygen free radicals occurs immediately after …

Heart failure is considered to be a complex clinical syndrome, with alterations in the multiple
neurohumoral systems and subcellular cardiac sites that correlate with abnormal cardiac …

Although oxidants such as superoxide (O 2.-) and hydrogen peroxide (H 2 O 2) play a role in
host-mediated destruction of foreign pathogens yet excessive generation of oxidants may …

Objectives In view of the critical role of intracellular Ca 2+-overload in the genesis of
myocyte dysfunction and the ability of reactive oxygen species (ROS) to induce the …