Involvement of oxidative stress in the development of subcellular defects and heart disease
NS Dhalla, V Elimban, M Bartekova, A Adameova - Biomedicines, 2022 - mdpi.com
It is now well known that oxidative stress promotes lipid peroxidation, protein oxidation,
activation of proteases, fragmentation of DNA and alteration in gene expression for …
activation of proteases, fragmentation of DNA and alteration in gene expression for …
Role of oxidative stress in cardiac dysfunction and subcellular defects due to ischemia-reperfusion injury
NS Dhalla, AK Shah, A Adameova, M Bartekova - Biomedicines, 2022 - mdpi.com
Ischemia-reperfusion (I/R) injury is well-known to be associated with impaired cardiac
function, massive arrhythmias, marked alterations in cardiac metabolism and irreversible …
function, massive arrhythmias, marked alterations in cardiac metabolism and irreversible …
Oxidative stress as a mechanism for functional alterations in cardiac hypertrophy and heart failure
AK Shah, SK Bhullar, V Elimban, NS Dhalla - Antioxidants, 2021 - mdpi.com
Although heart failure due to a wide variety of pathological stimuli including myocardial
infarction, pressure overload and volume overload is associated with cardiac hypertrophy …
infarction, pressure overload and volume overload is associated with cardiac hypertrophy …
[PDF][PDF] Oxidative stress and ischemic myocardial syndromes
Oxidative stress is a condition in which reactive oxygen species (ROS) or free radicals,
namely O2•–, H2O2, and• OH, are generated extra-or intracellularly and exert toxic effects …
namely O2•–, H2O2, and• OH, are generated extra-or intracellularly and exert toxic effects …
Potential role and mechanisms of subcellular remodeling in cardiac dysfunction due to ischemic heart disease
Several studies have revealed varying degrees of changes in sarcoplasmic reticular and
myofibrillar activities, protein content, gene expression and intracellular Ca 2+-handling …
myofibrillar activities, protein content, gene expression and intracellular Ca 2+-handling …
Redox-mediated reciprocal regulation of SERCA and Na+–Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes
GM Kuster, S Lancel, J Zhang, C Communal… - Free Radical Biology …, 2010 - Elsevier
Myocardial failure is associated with increased oxidative stress and abnormal excitation–
contraction coupling characterized by depletion of sarcoplasmic reticulum (SR) Ca2+ stores …
contraction coupling characterized by depletion of sarcoplasmic reticulum (SR) Ca2+ stores …
Oxygen free radicals and calcium homeostasis in the heart
M Kaneko, Y Matsumoto, H Hayashi… - Molecular and cellular …, 1994 - Springer
Many experiments have been done to clarify the effects of oxygen free radicals on Ca 2+
homeostasis in the hearts. A burst of oxygen free radicals occurs immediately after …
homeostasis in the hearts. A burst of oxygen free radicals occurs immediately after …
Oxidative stress in congestive heart failure
PK Singal, N Khaper, F Farahmand… - Current Cardiology …, 2000 - Springer
Heart failure is considered to be a complex clinical syndrome, with alterations in the multiple
neurohumoral systems and subcellular cardiac sites that correlate with abnormal cardiac …
neurohumoral systems and subcellular cardiac sites that correlate with abnormal cardiac …
Targets of oxidative stress in cardiovascular system
S Chakraborti, T Chakraborti, JR Michael… - Molecular and cellular …, 1998 - Springer
Although oxidants such as superoxide (O 2.-) and hydrogen peroxide (H 2 O 2) play a role in
host-mediated destruction of foreign pathogens yet excessive generation of oxidants may …
host-mediated destruction of foreign pathogens yet excessive generation of oxidants may …
Role of oxidative stress in cardiovascular diseases
NS Dhalla, RM Temsah, T Netticadan - Journal of hypertension, 2000 - journals.lww.com
Objectives In view of the critical role of intracellular Ca 2+-overload in the genesis of
myocyte dysfunction and the ability of reactive oxygen species (ROS) to induce the …
myocyte dysfunction and the ability of reactive oxygen species (ROS) to induce the …
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