ATP and its ultimate degradation product adenosine are potent extracellular signalling
molecules that elicit a variety of pathophysiological functions in the kidney through the …

Since purinergic signaling was discovered in the early 1970s, it has been shown that
extracellular nucleotides, and their derivative nucleosides, are released in a regulated or …

Abstract Extracellular adenosine 5′-triphosphate (ATP) and adenosine molecules are
intimately involved in immune responses. ATP is mostly a pro-inflammatory molecule and is …

ATP, NAD+, and nucleic acids are abundant purines that, in addition to having critical
intracellular functions, have evolved extracellular roles as danger signals released in …

Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the
extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling …

Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

Nucleotides are key subunits for nucleic acids and provide energy for intracellular
metabolism. They can also be released from cells to act physiologically as extracellular …

Extracellular ATP and ADP trigger inflammatory, vasodilatatory, and prothrombotic signaling
events in the vasculature, and their turnover is governed by networks of membrane …

Adenosine (Ado) is a well-studied neurotransmitter, but it also exerts profound immune
regulatory functions. Ado can (i) actively be released by various cells into the tissue …

Intracellular ATP is the most vital source of cellular energy for biologic systems, whereas
extracellular ATP is a multifaceted mediator of several cell functions via its interaction, in an …