Conversion of extracellular ATP into adenosine: a master switch in renal health and disease
KM Dwyer, BK Kishore, SC Robson - Nature Reviews Nephrology, 2020 - nature.com
ATP and its ultimate degradation product adenosine are potent extracellular signalling
molecules that elicit a variety of pathophysiological functions in the kidney through the …
molecules that elicit a variety of pathophysiological functions in the kidney through the …
Extracellular ATP signaling and clinical relevance
L Dou, YF Chen, PJ Cowan, XP Chen - Clinical Immunology, 2018 - Elsevier
Since purinergic signaling was discovered in the early 1970s, it has been shown that
extracellular nucleotides, and their derivative nucleosides, are released in a regulated or …
extracellular nucleotides, and their derivative nucleosides, are released in a regulated or …
Extracellular ATP and adenosine: the Yin and Yang in immune responses?
Abstract Extracellular adenosine 5′-triphosphate (ATP) and adenosine molecules are
intimately involved in immune responses. ATP is mostly a pro-inflammatory molecule and is …
intimately involved in immune responses. ATP is mostly a pro-inflammatory molecule and is …
Purine release, metabolism, and signaling in the inflammatory response
ATP, NAD+, and nucleic acids are abundant purines that, in addition to having critical
intracellular functions, have evolved extracellular roles as danger signals released in …
intracellular functions, have evolved extracellular roles as danger signals released in …
Purinergic regulation of the immune system
Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the
extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling …
extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling …
[HTML][HTML] Mechanisms of ATP release by inflammatory cells
Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …
[HTML][HTML] Purinergic signaling in kidney disease
Nucleotides are key subunits for nucleic acids and provide energy for intracellular
metabolism. They can also be released from cells to act physiologically as extracellular …
metabolism. They can also be released from cells to act physiologically as extracellular …
[HTML][HTML] Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities
GG Yegutkin, B Wieringa, SC Robson… - The FASEB …, 2012 - ncbi.nlm.nih.gov
Extracellular ATP and ADP trigger inflammatory, vasodilatatory, and prothrombotic signaling
events in the vasculature, and their turnover is governed by networks of membrane …
events in the vasculature, and their turnover is governed by networks of membrane …
[HTML][HTML] ATP and its metabolite adenosine as regulators of dendritic cell activity
C Silva-Vilches, S Ring, K Mahnke - Frontiers in immunology, 2018 - frontiersin.org
Adenosine (Ado) is a well-studied neurotransmitter, but it also exerts profound immune
regulatory functions. Ado can (i) actively be released by various cells into the tissue …
regulatory functions. Ado can (i) actively be released by various cells into the tissue …
The dark side of extracellular ATP in kidney diseases
Intracellular ATP is the most vital source of cellular energy for biologic systems, whereas
extracellular ATP is a multifaceted mediator of several cell functions via its interaction, in an …
extracellular ATP is a multifaceted mediator of several cell functions via its interaction, in an …