Abstract Streptothricin‐F (STT‐F), one of the early‐discovered antibiotics, consists of three
components, a β‐lysine homopolymer, an aminosugar d‐gulosamine, and an unusual …

The antibiotic streptothricin (ST) possesses an amino sugar bound to an l-β-lysine (β-Lys)
residue via a peptide bond. The peptide bond formation has been shown to be catalyzed by …

Streptogramin B antibiotics are cyclic peptide natural products produced by Streptomyces
species. In combination with the synergistic group A component, they are “last line of …

Mining microbial genomes including those of Streptomyces reveals the presence of a large
number of biosynthetic gene clusters. Unraveling this genetic potential has proved to be a …

Abstract Streptoseomycin (STM, 1) is a bacterial macrolactone that has a unique 5/14/10/6/6-
pentacyclic ring with an ether bridge. We have previously identified the biosynthetic gene …

A convergent, diversity-enabling total synthesis of the natural product streptothricin F has
been achieved. Herein, we describe the potent antimicrobial activity of streptothricin F and …

Streptonigrin is a potent antitumor antibiotic, active against a wide range of mammalian
tumor cells. It was reported that its biosynthesis relies on (2 S, 3 R)-β-methyltryptophan as an …

The pyrrolamides constitute a small family of secondary metabolites that are known for their
ability to bind noncovalently to the DNA minor groove with some sequence specificity. To …

Streptothricin F (STF, 1) is a peptidyl nucleoside antibiotic produced by Streptomyces
lavendulae. Studies were conducted to address the formation and timing of incorporation of …

Streptonigrin (STN, 1) is a highly functionalized aminoquinone alkaloid with broad and
potent antitumor activity. Here, we reported the biosynthetic gene cluster of STN identified by …