Adaptive immune response selects for postponed maturation and increased body size

MJ Ejsmond, J Radwan, A Ejsmond… - Functional …, 2023 - Wiley Online Library
Abstract The Major Histocompatibility Complex (MHC) genes encode proteins that initiate
the adaptive immune response by presenting pathogen‐derived antigenic peptides to T …

Sexual selection and the evolutionary dynamics of the major histocompatibility complex

M Jan Ejsmond, J Radwan… - Proceedings of the …, 2014 - royalsocietypublishing.org
The genes of the major histocompatibility complex (MHC) are a key component of the
adaptive immune system and among the most variable loci in the vertebrate genome …

Unfinished business: evolution of the MHC and the adaptive immune system of jawed vertebrates

J Kaufman - Annual review of immunology, 2018 - annualreviews.org
The major histocompatibility complex (MHC) is a large genetic region with many genes,
including the highly polymorphic classical class I and II genes that play crucial roles in …

[HTML][HTML] Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations

C Eizaguirre, TL Lenz, M Kalbe, M Milinski - Nature communications, 2012 - nature.com
The genes of the major histocompatibility complex are the most polymorphic genes in
vertebrates, with more than 1,000 alleles described in human populations. How this …

Does reduced MHC diversity decrease viability of vertebrate populations?

J Radwan, A Biedrzycka, W Babik - Biological conservation, 2010 - Elsevier
Loss of genetic variation may render populations more vulnerable to pathogens due to
inbreeding depression and depletion of variation in genes responsible for immunity against …

What do the paralogous regions in the genome tell us about the origin of the adaptive immune system?

M Kasahara - Immunological reviews, 1998 - Wiley Online Library
During the last decade, our understanding of the immune system of ectothermic vertebrates
has advanced significantly. It is now clear that all jawed vertebrates are equipped with the …

[HTML][HTML] Host–parasite network structure is associated with community-level immunogenetic diversity

S Pilosof, MA Fortuna, JF Cosson, M Galan… - Nature …, 2014 - nature.com
Genes of the major histocompatibility complex (MHC) encode proteins that recognize foreign
antigens and are thus crucial for immune response. In a population of a single host species …

[HTML][HTML] Pathogenic selection promotes adaptive immune variations against serious bottlenecks in early invasions of bullfrogs

J Zhang, S Wang, C Xu, S Wang, J Du, M Niu, J Yang… - Iscience, 2023 - cell.com
Adaptive genetic variations are key for understanding evolutionary processes influencing
invasions. However, we have limited knowledge on how adaptive genetic diversity in …

[HTML][HTML] Red Queen processes drive positive selection on major histocompatibility complex (MHC) genes

MJ Ejsmond, J Radwan - PLoS Computational Biology, 2015 - journals.plos.org
Major Histocompatibility Complex (MHC) genes code for proteins involved in the incitation of
the adaptive immune response in vertebrates, which is achieved through binding …

MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years?

L Bernatchez, C Landry - Journal of evolutionary biology, 2003 - academic.oup.com
Elucidating how natural selection promotes local adaptation in interaction with migration,
genetic drift and mutation is a central aim of evolutionary biology. While several conceptual …