Mitochondrial dysfunction triggered by increased reactive oxygen species (ROS) generation
is involved in the pathogenesis and development of cardiac hypertrophy. Nanoceria (cerium …

Background An altered state of cardiomyocytes due to high glucose concentrations results in
cell hypertrophy, leading to diabetic cardiomyopathy (DCM). The molecular regulatory …

Isoproterenol (ISO), a synthetic β 1 adrenergic agonist is a well-known agent to be
associated with severe cardiotoxicity manifested as marked myocardial necrosis and …

Abstract Objective: Cerium oxide (CeO2) nanoparticles have been shown to protect cells in
culture from lethal stress, but no protection in vivo has been reported. Cardiac-specific …

Cigarette smoke contains and generates a large amount of reactive oxygen species (ROS)
that affect normal cellular function and have pathogenic consequences in the cardiovascular …

Oxidative stress is well documented to cause injury to endothelial cells (ECs), which in turn
trigger cardiovascular diseases. Previous studies revealed that cerium oxide nanoparticles …

Doxorubicin (DOX) is one of the most commonly used anticancer drugs but its use has been
limited due to constraints of cardiotoxic side effects. The precise mechanism underlying …

Cerium oxide nanoparticles, also known as nanoceria, possess antioxidative and anti-
inflammatory activities in animal models of inflammatory disorders, such as sepsis. However …

Metabolic disorders often lead to cardiac complications. Metabolic deregulations during
diabetic conditions are linked to mitochondrial dysfunctions, which are the key contributing …

Abstract Background Cardiovascular diseases (CVDs) have the highest mortality worldwide.
Human pluripotent stem cells (hPSCs) and their cardiomyocyte derivatives (hPSC-CMs) …