Background Patients with sepsis have a high mortality rate, accumulated evidences suggest
that an optimal antibiotic administration strategy based on pharmacokinetics …

Background Antibiotic exposure in intensive care patients with sepsis is frequently
inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Objective β-lactams are the most widely used antibiotics in sepsis. We aimed to explore the
factors that drive physicians to choose prolonged infusion (PI) of β-lactams in septic patients …

Background The importance of optimising antimicrobial therapy is highlighted in the hospital
intensive care unit (ICU) patients. But roles of ICU pharmacists are still in its infancy in …

Abstract Pharmacokinetic-pharmacodynamic (PK-PD) analysis is important in selecting the
antimicrobial agent dosage for appropriate use. No information on the spread of dosage …

Background Septic shock is a global public health burden. In addition to the improvement of
the level of individual care, the improvement of the overall hospital quality control …

Objective. This study was to evaluate the efficacy of antimicrobial step-down therapy versus
conventional antimicrobial therapy in the treatment of patients with sepsis. Methods …

To the Editor: Sepsis and septic shock are a leading cause of intensive care unit (ICU)
admissions and induce significant morbidity and mortality.[1, 2] Early propitiate antibiotics …

Kalimouttou and colleagues [1] identified a bundle of six recommendations that was
associated with a dramatic reduction in mortality in sepsis and septic shock. Their work …