[HTML][HTML] Cryo-EM model validation recommendations based on outcomes of the 2019 EMDataResource challenge
This paper describes outcomes of the 2019 Cryo-EM Model Challenge. The goals were to
(1) assess the quality of models that can be produced from cryogenic electron microscopy …
(1) assess the quality of models that can be produced from cryogenic electron microscopy …
Residue-wise local quality estimation for protein models from cryo-EM maps
An increasing number of protein structures are being determined by cryogenic electron
microscopy (cryo-EM). Although the resolution of determined cryo-EM density maps is …
microscopy (cryo-EM). Although the resolution of determined cryo-EM density maps is …
[HTML][HTML] Deep learning for reconstructing protein structures from cryo-EM density maps: Recent advances and future directions
Abstract Cryo-Electron Microscopy (cryo-EM) has emerged as a key technology to determine
the structure of proteins, particularly large protein complexes and assemblies in recent …
the structure of proteins, particularly large protein complexes and assemblies in recent …
[HTML][HTML] RosettaES: a sampling strategy enabling automated interpretation of difficult cryo-EM maps
Accurate atomic modeling of macromolecular structures into cryo-electron microscopy (cryo-
EM) maps is a major challenge, as the moderate resolution makes accurate placement of …
EM) maps is a major challenge, as the moderate resolution makes accurate placement of …
EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
Advances in high-resolution cryo-electron microscopy (cryo-EM) require the development of
validation metrics to independently assess map quality and model geometry. We report …
validation metrics to independently assess map quality and model geometry. We report …
[HTML][HTML] DeepEMhancer: a deep learning solution for cryo-EM volume post-processing
Cryo-EM maps are valuable sources of information for protein structure modeling. However,
due to the loss of contrast at high frequencies, they generally need to be post-processed to …
due to the loss of contrast at high frequencies, they generally need to be post-processed to …
[HTML][HTML] Model building of protein complexes from intermediate-resolution cryo-EM maps with deep learning-guided automatic assembly
Advances in microscopy instruments and image processing algorithms have led to an
increasing number of cryo-electron microscopy (cryo-EM) maps. However, building accurate …
increasing number of cryo-electron microscopy (cryo-EM) maps. However, building accurate …
[HTML][HTML] New tools for the analysis and validation of cryo-EM maps and atomic models
PV Afonine, BP Klaholz, NW Moriarty… - … Section D: Structural …, 2018 - scripts.iucr.org
Recent advances in the field of electron cryomicroscopy (cryo-EM) have resulted in a rapidly
increasing number of atomic models of biomacromolecules that have been solved using this …
increasing number of atomic models of biomacromolecules that have been solved using this …
De Novo modeling in cryo-EM density maps with Pathwalking
As electron cryo-microscopy (cryo-EM) can now frequently achieve near atomic resolution,
accurate interpretation of these density maps in terms of atomistic detail has become …
accurate interpretation of these density maps in terms of atomistic detail has become …
[HTML][HTML] FSC-Q: a CryoEM map-to-atomic model quality validation based on the local Fourier shell correlation
In recent years, advances in cryoEM have dramatically increased the resolution of
reconstructions and, with it, the number of solved atomic models. It is widely accepted that …
reconstructions and, with it, the number of solved atomic models. It is widely accepted that …