Copying information is vital for life's propagation. Current life forms maintain a low error rate
in replication, using complex machinery to prevent and correct errors. However, primitive life …

Establishing programmable and self-sustaining replication networks in pools of chemical
reagents is a key challenge in systems chemistry. Self-replicating templates are formed from …

Unravelling how the complexity of living systems can (have) emerge (d) from simple
chemical reactions is one of the grand challenges in contemporary science. Evolving …

Self‐replication plays a central role in the origin of life and in strategies to synthesize life de
novo. Studies on self‐replication have focused mostly on isolated systems, while the …

Among the key characteristics of living systems are their ability to self‐replicate and the fact
that they exist in an open system away from equilibrium. Herein, we show how the outcome …

Dynamic combinatorial libraries (DCLs) are molecular networks in which the network
members exchange building blocks. The resulting product distribution is initially under …

A “self-replicator” is usually understood to be an object of definite form that promotes the
conversion of materials in its environment into a nearly identical copy of itself. The challenge …

Producing a polymer copy of a polymer template is central to biology, and effective copies
must persist after template separation. We show that this separation has three fundamental …

How does it work? It involves product-directed assembly of components to form a new
product. The simplest selfreplicating system entails the joining of only two components (see …

The emergence of functional replicases, acting quickly and with high accuracy, was crucial
to the origin of life 1. Although where the first RNA molecules came from is still unknown, it is …