Acute-phase response factor (APRF) is a transcription factor that blnds to the Interfeukln-6
(IL-@-responsive elements identlfled In the promoters of various acutephase protein genes …

Cytokines and growth factors elicit responses in target cells through induction of gene
expression. Signaling mechanisms leading to gene transcription from cell surface receptors …

Interleukin-6 (IL-6) is known to be a major mediator of the acute-phase response in liver. We
show here that IL-6 triggers the rapid activation of a nuclear factor, termed acute-phase …

Abstract Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin Μ, IL-11, and ciliary
neurotropic factor are a family of cytokines and neuronal differentiation factors which bind to …

The cytokine interleukin-6 (IL-6) rapidly activates a latent cytoplasmic transcription factor,
acute-phase response factor (APRF), by tyrosine phosphorylation. Activation and DNA …

Distinct yet overlapping sets of STAT transcription factors are activated by different cytokines.
One example is the differential activation of acute phase response factor (APRF, also called …

Interleukin-6 (IL-6) and γ-interferon (IFNγ) activate an overlapping set of genes via the
Jak/STAT pathway. However, at least in human cells, a differential activation of STAT …

Interleukin-6 (IL-6) and gamma interferon (IFN-γ) induce a partially overlapping set of genes,
including the genes for interferon regulatory factor 1 (IRF-1), intercellular adhesion molecule …

Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary
neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon …

We have identified a novel member of the interleukin-1 (IL-1) receptor family, which we have
termed AcPL. In transient transfection assays, we were unable to demonstrate a role for …