Chromatin states are functionally defined by a complex combination of histone
modifications, transcription factor binding, DNA accessibility and other factors. Current …

Probing histone modifications at a single-cell level in thousands of cells has been enabled
by technologies such as single-cell CUT&Tag. Here we describe nano-CUT&Tag (nano-CT) …

Modern next-generation sequencing-based methods have empowered researchers to assay
the epigenetic states of individual cells. Existing techniques for profiling epigenetic marks in …

Cleavage under targets and tagmentation (CUT&Tag) is an antibody-directed in situ
chromatin profiling strategy that is rapidly replacing immune precipitation-based methods …

Abstract We recently introduced Cleavage Under Targets & Tagmentation (CUT&Tag), an
epigenomic profiling strategy in which antibodies are bound to chromatin proteins in situ in …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-
throughput, single-cell assessment of heterochromatin and its underlying genomic …

The assay for transposase-accessible chromatin using sequencing (ATAC-seq) is widely
used to identify regulatory regions throughout the genome. However, very few studies have …

Chromatin accessibility mapping is a powerful approach to identify potential regulatory
elements. A popular example is ATAC-seq, whereby Tn5 transposase inserts sequencing …

Several limitations of current epigenomic technology preclude their use in many
experimental and clinical settings. Here we describe Assay for Transposase Accessible …