Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation
Y Ma, GV Halade, J Zhang, TA Ramirez… - Circulation …, 2013 - Am Heart Assoc
Rationale: Matrix metalloproteinase (MMP)-28 regulates the inflammatory and extracellular
matrix responses in cardiac aging, but the roles of MMP-28 after myocardial infarction (MI) …
matrix responses in cardiac aging, but the roles of MMP-28 after myocardial infarction (MI) …
Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution
RP Iyer, LE de Castro Brás, NL Patterson… - Journal of molecular and …, 2016 - Elsevier
Abstract Matrix metalloproteinase-9 (MMP-9) is robustly elevated in the first week post-
myocardial infarction (MI). Targeted deletion of the MMP-9 gene attenuates cardiac …
myocardial infarction (MI). Targeted deletion of the MMP-9 gene attenuates cardiac …
Early matrix metalloproteinase-12 inhibition worsens post-myocardial infarction cardiac dysfunction by delaying inflammation resolution
Abstract Rationale Matrix metalloproteinases (MMPs) regulate remodeling of the left
ventricle (LV) post-myocardial infarction (MI). MMP-12 has potent macrophage-dependent …
ventricle (LV) post-myocardial infarction (MI). MMP-12 has potent macrophage-dependent …
Matrix metalloproteinase-28 deletion amplifies inflammatory and extracellular matrix responses to cardiac aging
Y Ma, YA Chiao, J Zhang, AM Manicone… - Microscopy and …, 2012 - cambridge.org
To determine if matrix metalloproteinase (MMP)-28 mediates cardiac aging, wild-type (WT)
and MMP-28−/− young (7±1 months, n= 9 each) and old (20±2 months, n= 7 each) female …
and MMP-28−/− young (7±1 months, n= 9 each) and old (20±2 months, n= 7 each) female …
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
A Ducharme, S Frantz, M Aikawa… - The Journal of …, 2000 - Am Soc Clin Investig
Matrix metalloproteinase-9 (MMP-9) is prominently overexpressed after myocardial
infarction (MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less …
infarction (MI). We tested the hypothesis that mice with targeted deletion of MMP9 have less …
Myocardial infarction superimposed on aging: MMP-9 deletion promotes M2 macrophage polarization
A Yabluchanskiy, Y Ma… - … Series A: Biomedical …, 2016 - academic.oup.com
In this study, we examined the combined effect of aging and myocardial infarction on left
ventricular remodeling, focusing on matrix metalloproteinase (MMP)-9-dependent …
ventricular remodeling, focusing on matrix metalloproteinase (MMP)-9-dependent …
Myocardial protection from ischemia/reperfusion injury by targeted deletion of matrix metalloproteinase-9
AM Romanic, SM Harrison, W Bao… - Cardiovascular …, 2002 - academic.oup.com
Abstract Objective: Matrix metalloproteinase-9 (MMP-9) activity is up regulated in the heart
subjected to ischemic insult. Whether increased MMP-9 activity contributes to acute …
subjected to ischemic insult. Whether increased MMP-9 activity contributes to acute …
Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction
CA Meschiari, M Jung, RP Iyer… - American Journal …, 2018 - journals.physiology.org
Matrix metalloproteinase (MMP)-9 increases in the myocardium with advanced age and after
myocardial infarction (MI). Because young transgenic (TG) mice overexpressing human …
myocardial infarction (MI). Because young transgenic (TG) mice overexpressing human …
Transgenic overexpression of matrix metalloproteinase-9 in macrophages attenuates the inflammatory response and improves left ventricular function post-myocardial …
R Zamilpa, J Ibarra, LE de Castro Brás… - Journal of molecular and …, 2012 - Elsevier
Following myocardial infarction (MI), activated macrophages infiltrate into the necrotic
myocardium as part of a robust pro-inflammatory response and secrete matrix …
myocardium as part of a robust pro-inflammatory response and secrete matrix …
Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis
H Toba, PL Cannon, A Yabluchanskiy… - American Journal …, 2017 - journals.physiology.org
Advancing age is an independent risk factor for cardiovascular disease. Matrix
metalloproteinase-9 (MMP-9) is secreted by macrophages and robustly increases in the left …
metalloproteinase-9 (MMP-9) is secreted by macrophages and robustly increases in the left …
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