Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …
[HTML][HTML] The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops
NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress
responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing …
responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing …
Current landscape of NRF2 biomarkers in clinical trials
Y Yagishita, TN Gatbonton-Schwager, ML McCallum… - Antioxidants, 2020 - mdpi.com
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …
Transcriptional regulation by Nrf2
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
Advances and challenges in therapeutic targeting of NRF2
AT Dinkova-Kostova, IM Copple - Trends in pharmacological sciences, 2023 - cell.com
Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …
The role of Nrf2 in cardiovascular function and disease
S Satta, AM Mahmoud, FL Wilkinson… - Oxidative medicine …, 2017 - Wiley Online Library
Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …
Nrf2, the master regulator of anti-oxidative responses
S Vomund, A Schäfer, MJ Parnham, B Brüne… - International journal of …, 2017 - mdpi.com
Tight regulation of inflammation is very important to guarantee a balanced immune response
without developing chronic inflammation. One of the major mediators of the resolution of …
without developing chronic inflammation. One of the major mediators of the resolution of …
Recent advances in understanding Nrf2 agonism and its potential clinical application to metabolic and inflammatory diseases
Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …
NRF2, a transcription factor for stress response and beyond
F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …
cellular defense against toxic and oxidative insults through the expression of genes involved …
Modulating NRF2 in disease: timing is everything
M Dodson, MR de la Vega… - Annual review of …, 2019 - annualreviews.org
The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …
regulator of redox, metabolic, and protein homeostasis that intersects with many other …