Systems medicine has a mechanism-based rather than a symptom-or organ-based
approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In …

NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress
responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Tight regulation of inflammation is very important to guarantee a balanced immune response
without developing chronic inflammation. One of the major mediators of the resolution of …

Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …