Spatiotemporal translational regulation plays a key role in determining cell fate and function.
Specifically, in neurons, local translation in dendrites is essential for synaptic plasticity and …

Transport of RNAs to dendrites occurs in neuronal RNA granules, which allows local
synthesis of specific proteins at active synapses on demand, thereby contributing to learning …

RNA transport granules deliver translationally repressed mRNAs to synaptic sites in
dendrites, where synaptic activity promotes their localized translation. Although the identity …

Background RNA localization involves cis-motifs that are recognized by RNA-binding
proteins (RBP), which then mediate localization to specific sub-cellular compartments. RNA …

The subcellular localization and translation of messenger RNA (mRNA) supports functional
differentiation between cellular compartments. In neuronal dendrites, local translation of …

Localization of mRNAs to dendrites and local protein synthesis afford spatial and temporal
regulation of gene expression and endow synapses with the capacity to autonomously alter …

Local translation in neuronal dendrites is an important basis for long-term synaptic plasticity,
and RNA granules in the dendrites are involved in the local translation. Here, we identify …

Background Targeted transport of messenger RNA and local protein synthesis near the
synapse are important for synaptic plasticity. In order to gain an overview of the composition …

Neurons are morphologically complex cells that rely on the compartmentalization of protein
expression to develop and maintain their extraordinary cytoarchitecture. This formidable task …

ABSTRACT RNA localization to neuronal dendrites and axons is increasingly recognized as
a significant and widespread mechanism of gene expression control in neurons. High …