Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and
tolerance, inhibiting the expansion and function of many components of the immune system …

Transforming growth factor β (TGF-β) plays an important role in tumor initiation and
progression, functioning as both a suppressor and a promoter. The mechanisms underlying …

The immune system responds to cancer in two main ways. First, there are prewired
responses involving myeloid cells, innate lymphocytes and innate-like adaptive lymphocytes …

Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …

Since TGF-β was recognized as an essential secreted cytokine in embryogenesis and adult
tissue homeostasis a decade ago, our knowledge of the role of TGF-β in mammalian …

Transforming Growth Factor beta (TGF-β) is a pleiotropic cytokine produced in large
amounts within cancer microenvironments that will ultimately promote neoplastic …

Cancers may escape elimination by the host immune system by rewiring the tumour
microenvironment towards an immune suppressive state. Transforming growth factor-β (TGF …

Simple Summary Transforming growth factor beta (TGF-β) is a multifunctional cytokine that
can restrict cancer onset but also promote cancer progression at late stages of cancer. The …

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Immune homeostasis is a delicate balance between the immune defense against foreign
pathogens and suppression of the immune system to maintain self-tolerance and prevent …