Elimination of the left atrial appendage to prevent stroke or embolism?: anatomic, physiologic, and pathophysiologic considerations

C Stöllberger, B Schneider, J Finsterer - Chest, 2003 - Elsevier
The “elimination” of the left atrial appendage (LAA) seems to be an attractive alternative to
oral anticoagulation in the treatment of atrial fibrillation, especially in patients with …

The left atrial appendage in humans: structure, physiology, and pathogenesis

N Karim, SY Ho, E Nicol, W Li, F Zemrak… - EP …, 2020 - academic.oup.com
For many years, the left atrial appendage (LAA) was considered a dormant embryological
remnant; however, it is a structurally complex and functional organ that contributes to cardiac …

Is the left atrial appendage our most lethal attachment?

C Stöllberger, G Ernst, J Finsterer - European Journal of Cardio …, 2000 - academic.oup.com
Elimination of the left atrial appendage (LAA) might be an attractive alternative to
anticoagulation since over 90% of thrombi occur within the LAA. However, before discussing …

Left atrial appendage: physiology, pathology, and role as a therapeutic target

D Regazzoli, F Ancona, N Trevisi… - BioMed research …, 2015 - Wiley Online Library
Atrial fibrillation (AF) is the most common clinically relevant cardiac arrhythmia. AF poses
patients at increased risk of thromboembolism, in particular ischemic stroke. The CHADS2 …

Thrombogenic and arrhythmogenic roles of the left atrial appendage in atrial fibrillation: clinical implications

L Di Biase, A Natale, J Romero - Circulation, 2018 - Am Heart Assoc
Understanding the anatomy, physiology, and arrhythmogenic and thrombogenic roles of the
left atrial appendage (LAA) has become very important. The potential deleterious effects of …

Modification of the Left Atrial Appendage

MA Zenati, D Schwartzman - Innovative Management of Atrial …, 2005 - Wiley Online Library
Cardioembolism is the major cause of disability and death which can be clearly attributed to
atrial fibrillation (AF), particularly in the elderly [1–6]. Systemic anticoagulation with warfarin …

Nonthrombogenic Roles of the Left Atrial Appendage: JACC Review Topic of the Week

M Alkhouli, L Di Biase, A Natale, CS Rihal… - Journal of the American …, 2023 - jacc.org
The atrial appendage (LAA) is a well-established source of cardioembolism in patients with
atrial fibrillation. Therefore, research involving the LAA has largely focused on its …

Left atrial appendage: structure, function, and role in thromboembolism

NM Al-Saady, OA Obel, AJ Camm - Heart, 1999 - heart.bmj.com
The left atrial appendage (LAA) is derived from the left wall of the primary atrium, which
forms during the fourth week of embryonic development. It has developmental …

Left atrial appendage function and stroke risk

S Yaghi, C Song, WA Gray, KL Furie, MSV Elkind… - Stroke, 2015 - Am Heart Assoc
The LAA is the remnant of the embryonic left atrium, whereas the smooth-walled left atrium
originates from the primordial pulmonary vein and its branches. The LAA is largely …

Left atrial appendage: embryology, anatomy, physiology, arrhythmia and therapeutic intervention

N Naksuk, D Padmanabhan, V Yogeswaran… - JACC: Clinical …, 2016 - jacc.org
Known for the pathological connection to atrial fibrillation (AF), the left atrial appendage
(LAA) is the most common source of thromboembolism in patients with AF and may be an …