[HTML][HTML] A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches

P Radler, M Loose - European Journal of Cell Biology, 2023 - Elsevier
Bacteria divide by binary fission. The protein machine responsible for this process is the
divisome, a transient assembly of more than 30 proteins in and on the surface of the …

Macromolecular interactions of the bacterial division FtsZ protein: from quantitative biochemistry and crowding to reconstructing minimal divisomes in the test tube

G Rivas, C Alfonso, M Jiménez, B Monterroso… - Biophysical …, 2013 - Springer
The division of Escherichia coli is an essential process strictly regulated in time and space. It
requires the association of FtsZ with other proteins to assemble a dynamic ring during …

The ftsA* gain-of-function allele of Escherichia coli and its effects on the stability and dynamics of the Z ring

B Geissler, D Shiomi, W Margolin - Microbiology, 2007 - microbiologyresearch.org
Formation of the FtsZ ring (Z ring) in Escherichia coli is the first step in the assembly of the
divisome, a protein machine required for cell division. Although the biochemical functions of …

Disruption of divisome assembly rescued by FtsN–FtsA interaction in Escherichia coli

S Pichoff, S Du, J Lutkenhaus - Proceedings of the National …, 2018 - National Acad Sciences
Cell division requires the assembly of a protein complex called the divisome. The divisome
assembles in a hierarchical manner, with FtsA functioning as a hub to connect the Z-ring …

At the heart of bacterial cytokinesis: the Z ring

S Du, J Lutkenhaus - Trends in microbiology, 2019 - cell.com
Bacterial cell division is mediated by the divisome which is organized by the Z ring, a
cytoskeletal element formed by the polymerization of the tubulin homologue FtsZ. Despite …

Splitsville: structural and functional insights into the dynamic bacterial Z ring

DP Haeusser, W Margolin - Nature Reviews Microbiology, 2016 - nature.com
Bacteria must divide to increase in number and colonize their niche. Binary fission is the
most widespread means of bacterial cell division, but even this relatively simple mechanism …

Bacterial cell division: experimental and theoretical approaches to the divisome

CE Broughton, DI Roper, HA Van Den Berg… - Science …, 2015 - journals.sagepub.com
Cell division is a key event in the bacterial life cycle. It involves constriction at the midcell, so
that one cell can give rise to two daughter cells. This constriction is mediated by a ring …

Coordinated disassembly of the divisome complex in Escherichia coli

B Söderström, K Mirzadeh, S Toddo… - Molecular …, 2016 - Wiley Online Library
The divisome is the macromolecular complex that carries out cell division in Escherichia coli.
Every generation it must be assembled, and then disassembled so that the sequestered …

Localization, assembly, and activation of the Escherichia coli cell division machinery

PA Levin, A Janakiraman - EcoSal Plus, 2021 - Am Soc Microbiol
Decades of research, much of it in Escherichia coli, have yielded a wealth of insight into
bacterial cell division. Here, we provide an overview of the E. coli division machinery with an …

The bypass of ZipA by overexpression of FtsN requires a previously unknown conserved FtsN motif essential for FtsA–FtsN interaction supporting a model in which …

S Pichoff, S Du, J Lutkenhaus - Molecular microbiology, 2015 - Wiley Online Library
Assembly of the divisome in E scherichia coli occurs in two temporally distinct steps. First,
FtsZ filaments attached to the membrane through interaction with FtsA and ZipA coalesce …