Tuning the microenvironment to create functionally distinct mesenchymal stromal cell spheroids
Mesenchymal stromal cells (MSCs) are under investigation for wound healing and tissue
regeneration due to their potent secretome. Compared to monodisperse cells, MSC …
regeneration due to their potent secretome. Compared to monodisperse cells, MSC …
Multifactorial experimental design to optimize the anti-inflammatory and proangiogenic potential of mesenchymal stem cell spheroids
KC Murphy, J Whitehead, PC Falahee, D Zhou… - Stem Cells, 2017 - academic.oup.com
Mesenchymal stem cell therapies promote wound healing by manipulating the local
environment to enhance the function of host cells. Aggregation of mesenchymal stem cells …
environment to enhance the function of host cells. Aggregation of mesenchymal stem cells …
Engineering fibrin hydrogels to promote the wound healing potential of mesenchymal stem cell spheroids
Mesenchymal stem cells (MSCs) secrete endogenous factors such as vascular endothelial
growth factor (VEGF) and prostaglandin E2 (PGE 2) that promote angiogenesis, modulate …
growth factor (VEGF) and prostaglandin E2 (PGE 2) that promote angiogenesis, modulate …
Biomimetic culture strategies for the clinical expansion of mesenchymal stromal cells
Mesenchymal stromal/stem cells (MSCs) typically require significant ex vivo expansion to
achieve the high cell numbers required for research and clinical applications. However …
achieve the high cell numbers required for research and clinical applications. However …
Increased survival and function of mesenchymal stem cell spheroids entrapped in instructive alginate hydrogels
SS Ho, KC Murphy, BYK Binder… - Stem cells …, 2016 - academic.oup.com
Mesenchymal stem cell (MSC)-based therapies are under broad investigation for
applications in tissue repair but suffer from poor cell persistence and engraftment upon …
applications in tissue repair but suffer from poor cell persistence and engraftment upon …
Structurally and mechanically tuned macroporous hydrogels for scalable mesenchymal stem cell–extracellular matrix spheroid production
S Yin, H Wu, Y Huang, C Lu, J Cui, Y Li, B Xue… - Proceedings of the …, 2024 - pnas.org
Mesenchymal stem cells (MSCs) are essential in regenerative medicine. However,
conventional expansion and harvesting methods often fail to maintain the essential …
conventional expansion and harvesting methods often fail to maintain the essential …
Mesenchymal stromal cells as cell‐based therapeutics for wound healing
Chronic wounds are a source of substantial morbidity for patients and are a major financial
burden for the healthcare system. There are no current therapies that reliably improve …
burden for the healthcare system. There are no current therapies that reliably improve …
Strategies to capitalize on cell spheroid therapeutic potential for tissue repair and disease modeling
Cell therapies offer a tailorable, personalized treatment for use in tissue engineering to
address defects arising from trauma, inefficient wound repair, or congenital malformation …
address defects arising from trauma, inefficient wound repair, or congenital malformation …
[HTML][HTML] Production and administration of therapeutic mesenchymal stem/stromal cell (MSC) spheroids primed in 3-D cultures under xeno-free conditions
JH Ylostalo, N Bazhanov… - Journal of visualized …, 2017 - ncbi.nlm.nih.gov
Mesenchymal stem/stromal cells (MSCs) hold great promise in bioengineering and
regenerative medicine. MSCs can be isolated from multiple adult tissues via their strong …
regenerative medicine. MSCs can be isolated from multiple adult tissues via their strong …
Engineered Cell‐Secreted Extracellular Matrix Modulates Cell Spheroid Mechanosensing and Amplifies Their Response to Inductive Cues for the Formation of …
T Gonzalez‐Fernandez, AJ Tenorio… - Advanced …, 2022 - Wiley Online Library
The clinical translation of mesenchymal stromal cell (MSC)‐based therapies remains
challenging due to rapid cell death and poor control over cell behavior. Compared to …
challenging due to rapid cell death and poor control over cell behavior. Compared to …