The 26S proteasome irreversibly hydrolyzes polyubiquitylated substrates to maintain protein
homeostasis; it also regulates immune responses by generating antigenic peptides. An …

Four proteasome subtypes are commonly present in mammalian tissues: standard
proteasomes, which contain the standard catalytic subunits β1, β2 and β5; …

Vertebrates have evolved to express major histocompatibility complexes (MHCs) that
present peptides of the intra‐cellular proteome for immunosurveillance against viruses and …

The proteasome system in the cell degrades the majority of intracellular proteins. The broad
nature of its substrates makes proteasome activity crucial for many cellular functions, such …

Four proteasome subtypes are commonly present in mammalian tissues: standard
proteasomes, which contain the standard catalytic subunits β1, β2 and β5; …

Immunoproteasomes are considered to be optimised to process Ags and to alter the peptide
repertoire by generating a qualitatively different set of MHC class I epitopes. Whether the …

Immunoproteasome is a variant of proteasome with structural differences in 20S subunits
optimizing them for the production of antigenic peptides with higher binding affinity to major …

The majority of cellular proteins are degraded by proteasomes within the ubiquitin-
proteasome ATP-dependent degradation pathway. Products of proteasomal activity are …

Protein degradation by the proteasome releases peptides that can be loaded on MHC class
I molecules and presented to cytolytic T lymphocytes. Several mechanisms were recently …

The immunoproteasome (iP) has been proposed to perform specialized roles in MHC class I
antigen presentation, cytokine modulation, and T cell differentiation and has emerged as a …