Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comprise a spectrum
of neurodegenerative diseases linked to TDP-43 proteinopathy, which at the cellular level, is …

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by complex neuronal
and glial phenotypes. Recently, RNA-based mechanisms have been linked to ALS via RNA …

Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease
mostly affecting people around 50–60 years of age. TDP-43, an RNA-binding protein …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative disorders that are characterized by cytoplasmic aggregates and nuclear …

The RNA-binding protein TDP-43 has been linked to amyotrophic lateral sclerosis (ALS)
both as a causative locus and as a marker of pathology. With several missense mutations …

Rare mutations in TARDBP, the gene encoding TDP-43, cause amyotrophic lateral sclerosis
(ALS), and TDP-43 pathology is seen in a large majority of ALS patients, suggesting a …

Background Mutations in the small RNA-binding protein TDP-43 lead to the formation of
insoluble cytoplasmic aggregates that have been associated with the onset and progression …

Transactive response DNA-binding protein 43 kDa (TDP-43, also known as TBPH in
Drosophila melanogaster and TARDBP in mammals) is the main protein component of the …

Alteration and/or mutations of the ribonucleoprotein TDP-43 have been firmly linked to
human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and …

TDP-43 proteinopathy is strongly implicated in the pathogenesis of amyotrophic lateral
sclerosis and related neurodegenerative disorders. Whether TDP-43 neurotoxicity is caused …