Investigation of biological activity of 2, 3-disubstituted quinazolin-4 (1 H)-ones against Mycobacterium tuberculosis and DNA via docking, spectroscopy and DFT …

CBP Kumar, MS Raghu, KNN Prasad… - New Journal of …, 2021 - pubs.rsc.org
A series of 2, 3-disubstituted quinazolin-4 (1H)-ones (3a–j) were screened for their
antimicrobial activity via the minimum inhibitory concentration method (MIC). The in vitro anti …

Investigation of new 1,2,3-triazolyl-quinolinyl-propan-2-ol derivatives as potential antimicrobial agents: in vitro and in silico approach

AD Shinde, YM Nandurkar, S Bhalekar… - Journal of …, 2024 - Taylor & Francis
Abstract A new series of 1-((1-(4-substituted benzyl)-1 H-1, 2, 3-triazol-4-yl) methoxy)-2-(2-
substituted quinolin-4-yl) propan-2-ol (9a-x) have been synthesized. The newly synthesized …

Synthesis, anti-microbial and molecular docking studies of quinazolin-4 (3H)-one derivatives

YN Mabkhot, MS Al-Har, A Barakat, FD Aldawsari… - Molecules, 2014 - mdpi.com
In this work, synthesis, antimicrobial activities and molecular docking studies of some new
series of substituted quinazolinone 2a–h and 3a–d were described. Starting form 2 …

Oxazolyl-pyrimidines as antibacterial and antitubercular agents: synthesis, biological evaluation, in-silico ADMET and molecular docking study

KD Katariya, DV Reddy - Journal of Molecular Structure, 2022 - Elsevier
In search of novel biologically potent compounds, some new oxazolyl pyrimidines (7a-g)
have been prepared in the current investigation. All new compounds were characterized …

Synthesis, structural characterization and antibacterial activity evaluation of novel quinolone-1, 2, 3-triazole-benzimidazole hybrids

K El Gadali, M Rafya, M Maatallah, A Mehdi… - Journal of Molecular …, 2023 - Elsevier
In this investigation, a series of 2-quinolone-benzimidazole hybrids linked by a 1, 2, 3-
triazole moiety were prepared using copper-catalyzed Huisgen 1, 3-dipolar cycloaddition …

Synthesis, biological evaluation and molecular modelling insights of 2-arylquinazoline benzamide derivatives as anti-tubercular agents

S Malasala, MN Ahmad, J Gour, M Shukla… - Journal of Molecular …, 2020 - Elsevier
New 2-arylquinazoline benzamide derivatives were synthesized and screened against
H37RV strain, compounds displayed specific and potent anti-mycobacterial activity against …

Click approach for synthesis of 3, 4-dihydro-2 (1H) quinolinone, coumarin moored 1, 2, 3-triazoles as inhibitor of mycobacteria tuberculosis H37RV, their antioxidant …

NU Hebbar, AR Patil, P Gudimani, SL Shastri… - Journal of Molecular …, 2022 - Elsevier
In search of new potent molecules against tuberculosis, 3, 4-dihydro-2 (1H)-quinolinone
based 1, 2, 3-triazoles were synthesized efficiently by means of click chemistry and their …

Design, synthesis and molecular docking studies of quinazolin-4-ones linked to 1,2,3-triazol hybrids as Mycobacterium tuberculosis H37Rv inhibitors besides …

NK Maddali, IVK Viswanath*, YLN Murthy*… - Medicinal Chemistry …, 2019 - Springer
Abstract Quinazolin-4-ones linked to 1, 2, 3-triazol (10) were identified as inhibitors of the
bisphosphonate BPH-700 transcriptional factor from a high throughput screen. A series of 1 …

Molecular properties prediction and synthesis of novel 1, 3, 4-oxadiazole analogues as potent antimicrobial and antitubercular agents

MJ Ahsan, JG Samy, H Khalilullah, MS Nomani… - Bioorganic & medicinal …, 2011 - Elsevier
In the present investigation, a series of 1, 5-dimethyl-2-phenyl-4-{[(5-aryl-1, 3, 4-oxadiazol-2-
yl) methyl] amino}-1, 2-dihydro-3H-pyrazol-3-one were subjected to molecular properties …

[PDF][PDF] Design, synthesis, docking and biological study of pyrazole-3, 5-diamine derivatives with potent antitubercular activity

DC Pawar, SV Gaikwad, SS Kamble… - Chem …, 2022 - researchgate.net
Multidrug resistance tuberculosis (TB) is one of the major problems in the world, accounting
for morbidity and mortality [1, 2]. The literature report and per World Health Organization …