Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease

C Healy, N Munoz-Wolf, J Strydom, L Faherty… - Respiratory …, 2021 - Springer
Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and
copper by the host to limit pathogenicity by invading microorganisms. As one of the most …

The impact of metal availability on immune function during infection

AJ Monteith, EP Skaar - Trends in Endocrinology & Metabolism, 2021 - cell.com
Nutrient transition metals are required cofactors for many proteins to perform functions
necessary for life. As such, the concentration of nutrient metals is carefully maintained to …

[HTML][HTML] Immunomodulatory role of nutrients: how can pulmonary dysfunctions improve?

SC Gozzi-Silva, FME Teixeira, AJS Duarte… - Frontiers in …, 2021 - frontiersin.org
Nutrition is an important tool that can be used to modulate the immune response during
infectious diseases. In addition, through diet, important substrates are acquired for the …

Nutritional immunity: the battle for nutrient metals at the host–pathogen interface

CC Murdoch, EP Skaar - Nature Reviews Microbiology, 2022 - nature.com
Trace metals are essential micronutrients required for survival across all kingdoms of life.
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …

[PDF][PDF] The impact of dietary transition metals on host-bacterial interactions

CA Lopez, EP Skaar - Cell host & microbe, 2018 - cell.com
Transition metals are required cofactors for many proteins that are critical for life, and their
concentration within cells is carefully maintained to avoid both deficiency and toxicity. To …

Effects of metal compounds with distinct physicochemical properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadium

MD Cohen, M Sisco, C Prophete, K Yoshida… - Inhalation …, 2010 - Taylor & Francis
In situ reactions of metal ions or their compounds are important mechanisms by which
particles alter lung immune responses. The authors hypothesized that major determinants of …

Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner

M Roggenbuck, D Anderson, KK Barfod, M Feelisch… - Respiratory …, 2016 - Springer
Background Vitamin D is under scrutiny as a potential regulator of the development of
respiratory diseases characterised by chronic lung inflammation, including asthma and …

[HTML][HTML] The role of iron metabolism in lung inflammation and injury

J Kim, M Wessling-Resnick - Journal of allergy & therapy, 2012 - ncbi.nlm.nih.gov
Iron is required for many vital functions including oxygen transport and energy metabolism.
Protective mechanisms maintain optimal iron concentration involving dynamic regulation of …

Vitamin D-mediated effects on airway innate immunity in vitro

EM Stapleton, K Keck, R Windisch, MR Stroik… - PloS one, 2022 - journals.plos.org
Introduction Vitamin D supplementation has been suggested to enhance immunity during
respiratory infection season. We tested the effect of active vitamin D (calcitriol) …

Transition metal homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae

AG Turner, YO Cheryl-lynn, MJ Walker… - Advances in microbial …, 2017 - Elsevier
Trace metals such as Fe, Mn, Zn and Cu are essential for various biological functions
including proper innate immune function. The host immune system has complicated and …