Arrhythmogenic cardiomyopathy: exercise pitfalls, role of connexin-43, and moving beyond antiarrhythmics

IL Coscarella, M Landim-Vieira, JR Pinto… - International Journal of …, 2022 - mdpi.com
Arrhythmogenic Cardiomyopathy (ACM), a Mendelian disorder that can affect both left and
right ventricles, is most often associated with pathogenic desmosomal variants that can lead …

GJA1-20k rescues Cx43 localization and arrhythmias in arrhythmogenic cardiomyopathy

JA Palatinus, S Valdez, L Taylor, C Whisenant… - Circulation …, 2023 - Am Heart Assoc
Arrhythmogenic cardiomyopathy (ACM) is a heritable heart muscle disease associated with
increased risk of sudden cardiac death. The only treatment proven to reduce this risk is an …

Arrhythmogenic cardiomyopathy: pathology, genetics, and concepts in pathogenesis

ET Hoorntje, WP Te Rijdt, CA James… - Cardiovascular …, 2017 - academic.oup.com
Arrhythmogenic cardiomyopathy (ACM) is a rare, heritable heart disease characterized by
fibro-fatty replacement of the myocardium and a high degree of electric instability. It was first …

Arrhythmogenic cardiomyopathy: Molecular insights for improved therapeutic design

TL Stevens, MJ Wallace, M El Refaey… - Journal of …, 2020 - mdpi.com
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by structural
and electrical cardiac abnormalities, including myocardial fibro-fatty replacement. Its …

Established and emerging mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy: a multifaceted disease

S Gao, D Puthenvedu, R Lombardi… - International Journal of …, 2020 - mdpi.com
Arrhythmogenic cardiomyopathy (ACM) is a heritable myocardial disease that manifests with
cardiac arrhythmias, syncope, sudden cardiac death, and heart failure in the advanced …

[HTML][HTML] In Vivo Approaches to Understand Arrhythmogenic Cardiomyopathy: Perspectives on Animal Models

G Risato, R Brañas Casas, M Cason, M Bueno Marinas… - Cells, 2024 - mdpi.com
Arrhythmogenic cardiomyopathy (AC) is a hereditary cardiac disorder characterized by the
gradual replacement of cardiomyocytes with fibrous and adipose tissue, leading to …

Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure

J Yan, C Killingsworth, G Walcott, Y Zhu… - Journal of molecular and …, 2021 - Elsevier
Background Both gap junctional remodeling and interstitial fibrosis have been linked to
impaired electrical conduction velocity (CV) and fatal ventricular arrhythmias in nonischemic …

Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy

Q Jin, KY Lee, Z Selimi, D Shimura, E Wang… - Journal of molecular and …, 2024 - Elsevier
Gap junction and ion channel remodeling occur early in Arrhythmogenic Cardiomyopathy
(ACM), but their pathogenic consequences have not been elucidated. Here, we identified …

Pathophysiology of arrhythmogenic cardiomyopathy

C Basso, B Bauce, D Corrado, G Thiene - Nature Reviews Cardiology, 2012 - nature.com
Arrhythmogenic cardiomyopathy (AC) is a clinically and genetically heterogeneous disorder
of heart muscle that is associated with ventricular arrhythmias and risk of sudden cardiac …

Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy

A Asimaki, S Kapoor, E Plovie, A Karin Arndt… - Science translational …, 2014 - science.org
Arrhythmogenic cardiomyopathy (ACM) is characterized by frequent cardiac arrhythmias. To
elucidate the underlying mechanisms and discover potential chemical modifiers, we created …