Arrhythmogenic cardiomyopathy: exercise pitfalls, role of connexin-43, and moving beyond antiarrhythmics
IL Coscarella, M Landim-Vieira, JR Pinto… - International Journal of …, 2022 - mdpi.com
Arrhythmogenic Cardiomyopathy (ACM), a Mendelian disorder that can affect both left and
right ventricles, is most often associated with pathogenic desmosomal variants that can lead …
right ventricles, is most often associated with pathogenic desmosomal variants that can lead …
GJA1-20k rescues Cx43 localization and arrhythmias in arrhythmogenic cardiomyopathy
JA Palatinus, S Valdez, L Taylor, C Whisenant… - Circulation …, 2023 - Am Heart Assoc
Arrhythmogenic cardiomyopathy (ACM) is a heritable heart muscle disease associated with
increased risk of sudden cardiac death. The only treatment proven to reduce this risk is an …
increased risk of sudden cardiac death. The only treatment proven to reduce this risk is an …
Arrhythmogenic cardiomyopathy: pathology, genetics, and concepts in pathogenesis
ET Hoorntje, WP Te Rijdt, CA James… - Cardiovascular …, 2017 - academic.oup.com
Arrhythmogenic cardiomyopathy (ACM) is a rare, heritable heart disease characterized by
fibro-fatty replacement of the myocardium and a high degree of electric instability. It was first …
fibro-fatty replacement of the myocardium and a high degree of electric instability. It was first …
Arrhythmogenic cardiomyopathy: Molecular insights for improved therapeutic design
TL Stevens, MJ Wallace, M El Refaey… - Journal of …, 2020 - mdpi.com
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by structural
and electrical cardiac abnormalities, including myocardial fibro-fatty replacement. Its …
and electrical cardiac abnormalities, including myocardial fibro-fatty replacement. Its …
Established and emerging mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy: a multifaceted disease
S Gao, D Puthenvedu, R Lombardi… - International Journal of …, 2020 - mdpi.com
Arrhythmogenic cardiomyopathy (ACM) is a heritable myocardial disease that manifests with
cardiac arrhythmias, syncope, sudden cardiac death, and heart failure in the advanced …
cardiac arrhythmias, syncope, sudden cardiac death, and heart failure in the advanced …
[HTML][HTML] In Vivo Approaches to Understand Arrhythmogenic Cardiomyopathy: Perspectives on Animal Models
G Risato, R Brañas Casas, M Cason, M Bueno Marinas… - Cells, 2024 - mdpi.com
Arrhythmogenic cardiomyopathy (AC) is a hereditary cardiac disorder characterized by the
gradual replacement of cardiomyocytes with fibrous and adipose tissue, leading to …
gradual replacement of cardiomyocytes with fibrous and adipose tissue, leading to …
Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure
J Yan, C Killingsworth, G Walcott, Y Zhu… - Journal of molecular and …, 2021 - Elsevier
Background Both gap junctional remodeling and interstitial fibrosis have been linked to
impaired electrical conduction velocity (CV) and fatal ventricular arrhythmias in nonischemic …
impaired electrical conduction velocity (CV) and fatal ventricular arrhythmias in nonischemic …
Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy
Gap junction and ion channel remodeling occur early in Arrhythmogenic Cardiomyopathy
(ACM), but their pathogenic consequences have not been elucidated. Here, we identified …
(ACM), but their pathogenic consequences have not been elucidated. Here, we identified …
Pathophysiology of arrhythmogenic cardiomyopathy
Arrhythmogenic cardiomyopathy (AC) is a clinically and genetically heterogeneous disorder
of heart muscle that is associated with ventricular arrhythmias and risk of sudden cardiac …
of heart muscle that is associated with ventricular arrhythmias and risk of sudden cardiac …
Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy
A Asimaki, S Kapoor, E Plovie, A Karin Arndt… - Science translational …, 2014 - science.org
Arrhythmogenic cardiomyopathy (ACM) is characterized by frequent cardiac arrhythmias. To
elucidate the underlying mechanisms and discover potential chemical modifiers, we created …
elucidate the underlying mechanisms and discover potential chemical modifiers, we created …
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