During acute human viral infections, such as influenza A, specific cytotoxic T lymphocytes
(CTL) are generated which aid virus clearance. We have observed that in HLA-A* 0201+ …

We have shown that the dominance of CD8+ T cells expressing TCR Vβ17 in the adult HLA-
A* 0201-restricted influenza A/M158–66-specific response is acquired following first antigen …

The major histocompatibility complex class I-restricted cytotoxic T lymphocyte (CTL)
response is important in the clearance of viral infections in humans. After influenza A …

Recent studies have demonstrated biased usage of TCR Vβ17 and a high degree of
diversity in Jβ usage within the influenza virus matrix epitope (M. 58-66)-specific CTL …

Early studies of influenza virus-specific CD8+ T cell-mediated immunity indicated that the
level of CTL activity associated with H2D b is greatly diminished in mice that also express …

The H-2D b-restricted CD8 T cell immune response to influenza A is directed at two well-
described epitopes, nucleoprotein 366 (NP366) and acid polymerase 224 (PA224). The …

Current influenza A virus (IAV) vaccines stimulate antibody responses that are directed
against variable regions of the virus, and are therefore ineffective against divergent strains …

Understanding CD8+ T cell responses generated by live virus vectors is critical for the
rational design of next generation HIV CTL-based vaccines. We used recombinant influenza …

Little is known about the mechanisms governing TCR repertoire selection in response to
foreign antigens. Here, we evaluate the molecular features of the murine C57BL/6 (B6) TCR …

The human HLA-A2–restricted CD8+ T cell response to influenza A virus (IAV) is largely
directed against the matrix protein-derived M1 58–66 epitope and represents an archetypal …