Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage

R Muniyappa, S Lee, H Chen… - American Journal of …, 2008 - journals.physiology.org
Insulin resistance contributes to the pathophysiology of diabetes and is a hallmark of
obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying …

[HTML][HTML] Assessment of methods and indexes of insulin sensitivity

RS Patarrão, WW Lautt, MP Macedo - Revista Portuguesa de …, 2014 - Elsevier
Insulin resistance contributes to the pathophysiology of diabetes and is a hallmark of
obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying …

Limitations in surrogate measures of insulin resistance

TA Buchanan, RM Watanabe… - The Journal of Clinical …, 2010 - academic.oup.com
“Insulin resistance” is a loosely defined term that implies a reduction below normal in the
ability of insulin to mediate one of its physiological functions. The term is usually applied in …

Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats

R Muniyappa, H Chen, RH Muzumdar… - American journal …, 2009 - journals.physiology.org
Assessing insulin resistance in rodent models gives insight into mechanisms that cause type
2 diabetes and the metabolic syndrome. The hyperinsulinemic euglycemic glucose clamp …

The biochemical assessment of insulin resistance

A Borai, C Livingstone… - Annals of clinical …, 2007 - journals.sagepub.com
Insulin resistance is a common condition, recognized to be a central feature of the metabolic
syndrome, and strongly associated with an increased risk of cardiovascular disease and …

[HTML][HTML] Assessing insulin sensitivity and resistance in humans

R Muniyappa, R Madan, RT Varghese - 2015 - europepmc.org
In this chapter we discuss a representative variety of methods currently available for
estimating insulin sensitivity/resistance. These range from complex, time consuming, labor …

Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans

A Katz, SS Nambi, K Mather, AD Baron… - The Journal of …, 2000 - academic.oup.com
Insulin resistance plays an important role in the pathophysiology of diabetes and is
associated with obesity and other cardiovascular risk factors. The “gold standard” glucose …

Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice

S Lee, R Muniyappa, XU Yan, H Chen… - American Journal …, 2008 - journals.physiology.org
Insulin resistance contributes to the pathophysiology of diabetes, obesity, and their
cardiovascular complications. Mouse models of these human diseases are useful for …

[HTML][HTML] Surrogate markers of insulin resistance: A review

B Singh, A Saxena - World journal of diabetes, 2010 - ncbi.nlm.nih.gov
Insulin resistance is a hallmark of obesity, diabetes, and cardiovascular diseases, and leads
to many of the abnormalities associated with metabolic syndrome. Our understanding of …

How can we measure insulin sensitivity/resistance?

B Antuna-Puente, E Disse, R Rabasa-Lhoret… - Diabetes & …, 2011 - Elsevier
Insulin resistance represents a major public health problem, as it plays a major role in the
pathophysiology of type 2 diabetes mellitus; it is also associated with increased …