Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents

RPF Schins, JH Lightbody, PJA Borm, T Shi… - Toxicology and applied …, 2004 - Elsevier
There is conflicting evidence in the literature as to the predominant mechanism and also the
compositional element (s) that drives the pulmonary inflammatory response of ambient …

Chemical compositions responsible for inflammation and tissue damage in the mouse lung by coarse and fine particulate samples from contrasting air pollution in …

MS Happo, MR Hirvonen, AI Hälinen, PI Jalava… - Inhalation …, 2008 - Taylor & Francis
Inflammation is regarded as an important mechanism in mortality and morbidity associated
with exposures of cardiorespiratory patients to urban air particulate matter. We investigated …

Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities

MS Happo, RO Salonen, AI Hälinen, PI Jalava… - Inhalation …, 2010 - Taylor & Francis
The authors have previously demonstrated heterogeneities in the inflammatory activities of
urban air fine (PM2. 5–0.2) and coarse (PM10–2.5) particulate samples collected from six …

[HTML][HTML] Cytokine release from alveolar macrophages exposed to ambient particulate matter: heterogeneity in relation to size, city and season

RB Hetland, FR Cassee, M Låg, M Refsnes… - Particle and fibre …, 2005 - Springer
Background Several studies have demonstrated an association between exposure to
ambient particulate matter (PM) and respiratory and cardiovascular diseases. Inflammation …

Dose and time dependency of inflammatory responses in the mouse lung to urban air coarse, fine, and ultrafine particles from six European cities

MS Happo, RO Salonen, AI Hälinen, PI Jalava… - Inhalation …, 2007 - Taylor & Francis
We investigated the dose and time dependency of inflammatory and cytotoxic responses to
size-segregated urban air particulate samples in the mouse lung. Coarse (PM10− 2.5), fine …

Pro-inflammatory effects and oxidative stress in lung macrophages and epithelial cells induced by ambient particulate matter

S Michael, M Montag, W Dott - Environmental pollution, 2013 - Elsevier
The objective of this study was to compare the toxicological effects of different source-related
ambient PM10 samples in regard to their chemical composition. In this context we …

Murine pulmonary inflammatory responses following instillation of size-fractionated ambient particulate matter

CAJ Dick, P Singh, M Daniels, P Evansky… - Journal of toxicology …, 2003 - Taylor & Francis
The mechanisms for increased cardiopulmonary disease in individuals exposed to
particulate air pollution are associated with fine and ultrafine particles that have a high …

Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line

PI Jalava, MR Hirvonen, M Sillanpää… - Inhalation …, 2009 - Taylor & Francis
Epidemiological studies show heterogeneities in the particulate pollution-related exposure–
effect relationships among cardiorespiratory patients, but the connection to chemical …

The two PM2. 5 (fine) and PM2. 5–10 (coarse) fractions: evidence of different biological activity

M Diociaiuti, M Balduzzi, B De Berardis, G Cattani… - Environmental …, 2001 - Elsevier
Recent studies have shown that an increased concentration of environmental particulate
matter (PM10) is related to many respiratory diseases. One major issue is whether the …

Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine (PM2. 5) and coarse particles (PM10–2.5) in outdoor and indoor air

C Monn, S Becker - Toxicology and applied pharmacology, 1999 - Elsevier
Increased incidence of mortality and morbidity due to cardiopulmonary complications has
been found to associate with elevated levels of particulate air pollution (particulate matter …