A gap in our understanding of the beneficial systemic responses to dietary constituents
nitrate (NO 3−), nitrite (NO 2−) and conjugated linoleic acid (cLA) is the identification of the …

Fatty acid nitroalkenes (NO 2-FA) are endogenously-generated products of the reaction of
metabolic and inflammatory-derived nitrogen dioxide (. NO 2) with unsaturated fatty acids …

Dietary NO3−(nitrate) and NO2−(nitrite) support˙ NO (nitric oxide) generation and
downstream vascular signaling responses. These nitrogen oxides also generate secondary …

The oxidation and nitration of unsaturated fatty acids by oxides of nitrogen yield electrophilic
derivatives that can modulate protein function via post-translational protein modifications …

Nitrated derivatives of fatty acids (NO 2-FA) are pluripotent cell-signaling mediators that
display anti-inflammatory properties. Current understanding of NO 2-FA signal transduction …

Highlights•Formation of nitro-fatty acids.•Signaling of nitro-fatty acids.•Anti-fibrotic effects of
nitro-fatty acids.Fatty acids not only provide caloric energy in our diets and building blocks of …

Electrophilic fatty acid nitroalkenes (NO 2-FA) are products of nitric oxide and nitrite-
mediated unsaturated fatty acid nitration. These electrophilic products induce pleiotropic …

Conjugated linoleic acid (CLA) is a prime substrate for intra-gastric nitration giving rise to the
formation of nitro-conjugated linoleic acid (NO 2-CLA). Herein, NO 2-CLA generation is …

Nitroalkene fatty acids are formed in vivo and exert protective and anti-inflammatory effects
via reversible Michael addition to thiol-containing proteins in key signaling pathways. Nitro …

Nitroalkene derivatives of fatty acids act as adaptive, anti-inflammatory signalling mediators,
based on their high-affinity PPARγ (peroxisome-proliferator-activated receptor γ) ligand …