Synthesis of [60] Fullerene Hybrids Endowed with Steroids and Monosaccharides: Theoretical Underpinning as Promising anti‐SARS‐CoV‐2 Agents

R Lemos, K Makowski, L Almagro… - European Journal of …, 2023 - Wiley Online Library
Cyclopropanation reactions between C60 and different malonates decorated with
monosaccharides and steroids using the Bingel‐Hirsch methodology have allowed the …

An Androsterone‐H2@C60 hybrid: Synthesis, Properties and Molecular Docking Simulations with SARS‐Cov‐2

M Suárez, K Makowski, R Lemos, L Almagro… - …, 2021 - Wiley Online Library
We report the synthesis and characterization of a fullerene‐steroid hybrid that contains H2@
C60 and a dehydroepiandrosterone moiety synthesized by a cyclopropanation reaction with …

Diastereoselective synthesis of steroid–[60] fullerene hybrids and theoretical underpinning

D Alonso, D Hernández-Castillo… - The Journal of …, 2020 - ACS Publications
The reaction of C60 with pregnen-20-carboxaldehyde, a biologically active synthetic steroid,
by using a 1, 3-dipolar cycloaddition reaction (Prato's protocol) results in the formation of …

[60] Fullerene Hybrids Bearing “Steroid Wings”: A Joined Experimental and Theoretical Investigation

L Almagro, R Lemos, K Makowski… - European Journal of …, 2020 - Wiley Online Library
Novel [60] fullerene‐steroid hybrids have been synthesized by Bingel–Hirsch
cyclopropanation reaction between C60 and steroid malonates, leading to conjugates in …

Functionalized Fullerene for Inhibition of SARS‐CoV‐2 Variants

TM Page, C Nie, L Neander, TL Povolotsky, AK Sahoo… - small, 2023 - Wiley Online Library
As virus outbreaks continue to pose a challenge, a nonspecific viral inhibitor can provide
significant benefits, especially against respiratory viruses. Polyglycerol sulfates recently …

Anticoronavirus Activity of Water-Soluble Pristine C60 Fullerenes: In Vitro and In SilicoScreenings

V Hurmach, M Platonov, S Prylutska, Z Klestova… - … Therapeutics–Volume I …, 2022 - Springer
Introduction: The emergence of a new member of the Coronaviridae family, which caused
the 2020 pandemic, requires detailed research on the evolution of coronaviruses, their …

Fullerenes against COVID-19: Repurposing C60 and C70 to Clog the Active Site of SARS-CoV-2 Protease

TD Marforio, EJ Mattioli, F Zerbetto, M Calvaresi - Molecules, 2022 - mdpi.com
The persistency of COVID-19 in the world and the continuous rise of its variants demand
new treatments to complement vaccines. Computational chemistry can assist in the …

C60 fullerene against SARS-CoV-2 coronavirus: an in silico insight

VV Hurmach, MO Platonov, SV Prylutska, P Scharff… - Scientific reports, 2021 - nature.com
Based on WHO reports the new SARS-CoV-2 coronavirus is currently widespread all over
the world. So far> 162 million cases have been confirmed, including> 3 million deaths …

Steroid-fullerene hybrids: a review

M Ibrahim-Ouali, F Dumur - ARKIVOC-Online Journal of Organic …, 2022 - hal.science
Among carbon-based materials, fullerenes have emerged as very fascinating nanocarbons
on account of the interesting properties and applications of some of their derivatives in …

Functional Chimeras: New Bingel–Hirsch‐Type Steroid–Fullerene Hybrids

J Coro, H Rodriguez, DG Rivera, M Suarez, D Molero… - 2009 - Wiley Online Library
Cyclopropanations between C60 and readily available malonates bearing different steroid
moieties (4–6) by the Bingel–Hirsch protocol has allowed the synthesis of a new series of …